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Mechanisms of normal and abnormal neurulation: evidence from embryo culture studies

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Figure

Fig. 1. De novo initiationsites of neurulation,IA) Diagramof SIres anddirecflOnsof neural tube closurealong the body a,\is, as projectedonto anembryofollowingaXial rotation.The hindbramneuroporeliesbetweenclosurePOintsI and 2, the anteriorneuroporebetween2 and 3 and theposteriorneuroporeis the mostcaudal regionremainingfrom closure,.ModifiedafterCoppandBernfield(199-1).IBI Viewfromthefrontofthecranial region (directionof view mdlcatedby black arrow In AI of a pre-axialrotationembryoillustratingclosures2 and 3 and locationof the anteriorneuropore.
Fig. 2. Theinositol/lipidcycle.Free inositolis takenInto cells via a specificreceptorand convertedto inositolphospholipids.Undertheinfluenceof agonist-receptorbinding.thephospholipidsarecleavedby phospholipaseC to yieldinositolphosphatesanddiacylglycerol,e
Fig. 3_The principalmetabolicAbbreviations:pathwaysinvolvingfolate,methionineand homocysteine.SAH, S-adenosylhomocysteine;SAM.S-adenosylmerhionine;THF, tetrahydrofolate;DHF,dihydrofolate;5-CH3THF.5-methy/tetrahydrofolate;5,10-CH]THF.5,10-methyleneterra-hyd

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