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Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor

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Figure

Figure 1: The morphological changes in OTS167-treated cancer cells. A., B. MDA-MB-231 (A) or A549 (B) cells were treated with OTS167 at a given concentration (nM)
Figure 2: The expression of downstream molecules in OTS167-treated cells. A. DEPDC1 expression in MELK knocked-down cells
Figure 3: In vivo study of OTS167. A. Schematic presentation of the animal study. s.c injection; subcutaneous injection
Figure 4: MELK and Ki67 expression in OTS167-treated tumor tissue. A. Western blot analysis of MELK, DEPDC1, Snail, p21 and p53 in A549 xenograft tumor tissues
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