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Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis based medicines

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Table 1. Chromatographic conditions for the detection of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in rat plasma, in vitro lipolysis medium fractions, artificial lipid particles emulsion, and chylomicrons (CM) emulsion using high performance liquid chromatography (HPLC)
Figure 1. Plasma concentration-time profiles of ∆9-tetrahydrocannabinol (THC) following IV bolus (4 mg/kg, n = 5), oral lipid-free formulation (12 mg/kg, n = 6), and oral long-chain triglyceride (LCT)-based formulation (12 mg/kg, n = 5) to rats
Table 2. Pharmacokinetic parameters (mean ± SEM) derived from plasma concentration-time profiles following the administration of IV bolus (4 mg/kg), oral lipid-free formulation (12 mg/kg), and long chain triglyceride (LCT)-based formulation (12 mg/kg) of ∆9-tetrahydrocannabinol (THC) to rats
Table 3. Pharmacokinetic parameters (mean ± SEM) derived from plasma concentration-time profiles following the administration of IV bolus (4 mg/kg), oral lipid-free formulation (12 mg/kg), and long chain triglyceride (LCT)-based formulation (12 mg/kg) of cannabidiol (CBD) to rats
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