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TERT promoter mutations in melanoma render TERT expression dependent on MAPK pathway activation

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Figure

Table 1: Mutational status of cell lines used in this study
Figure 2: TERT expression is dependent on MAPK pathway activation. (A) Levels of TERT, phosphorylated ETS1 (pETS1), total ETS1 (ETS1), phosphorylated ERK (ppERK), total ERK (ERK) and actin were analyzed by western blotting in melanocytes (NHEM) and melanom
Figure 3: ETS1 binds to the TERT promoter and control its expression. (A) Luciferase reporter constructs containing wild type TERT promoter sequence (WT) and sequence with mutant allele for the –124T mutant (-124T) were transfected in triplicate into UKRV-

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