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Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP dependent nuclear accumulation of zyxin and Akt

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Figure

Figure 1ANP exposure exerts concentration-dependent antiapoptotic effects upon cardiomyocytes and is protective in vivo
Figure 2ANP induces nuclear accumulation of zyxin at antiapoptotic concentration. Immunolabeling (A and B) and quantitation of nuclear labeling  (C and D) in cultured cardiomyocytes treated with ANP (10–9 for 1 hour for A, B, and D; 10–6 M for 1 hour also
Figure 3Nuclear accumulation of zyxin is antiapoptotic. TUNEL assay (
Figure 4Nuclear accumulation of activated Akt kinase in response to ANP treatment or expression of nuclear-targeted zyxin
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