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Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E BP1 translation regulator

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Figure

Figure 1Akt-mTOR pathway. Activities of Akt, mTORC1 (Raptor complex),
Figure 2MCV sT antigen protein is commonly expressed in MCC. Immunohistochemical staining of adjacent slides from 2 MCC cases with mouse mAbs to MCV sT (CM5E1 antibody) and MCV LT (CM2B4 antibody) is shown
Figure 3MCV sT expression is required for growth, but not survival, of MCV-positive MCC cells
Figure 4MCV sT induces PP2A-binding and DnaJ domain–independent transformation of Rat-1 cells
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