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Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine

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Figure

Figure 1: Changes in amino acid levels in liver tissues from miR122-silenced mice. Results of amino acid analyses of liver tissues from control and miR122-silenced transgenic mice (n = 2 each)
Figure 2: Reduced miR122 is linked with resistance against sorafenib. (a) The firefly luciferase-based reporter with miR122 3’UTR responsive elements was transfected along with the Renilla luciferase-based control reporter
Figure 3: Arginine depletion decreases NO levels in miR122-silenced Huh7 cells. (a) Intracellular arginine levels decreased in miR122-silenced cells under arginine-depleted conditions
Figure 4: Forced miR122 expression sensitizes Hep3B cells to sorafenib treatment. (a, b)flow cytometry (f) and fluorescence microscopy (g)
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