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COVID-19 rapid guideline: Vaccine Induced Thrombosis and Thrombocytopenia (VITT)

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List of expert panel members and declarations of interest

Name Job title and

organisation Type of

interest Description of interest Relevant

dates Comments Susan

Bewley (Chair)

Professor Emeritus (honorary) in Obstetrics &

Women’s Health, King’s College London

Non- financial professional and

personal

Chair the charity Healthwatch-UK (‘for science & integrity in medicine’), and a Trustee of Maternity Action.

Ongoing Declare and participate.

Interest is non- specific Susan

Bewley (Chair)

Professor Emeritus (honorary) in Obstetrics &

Women’s Health, King’s College London

Non- financial professional and

personal

co-author of the BMJ article about 2019 CG144 Update https://www.bmj.com/contentI /369/bmj.m1565

2019 Declare and participate.

Interest is out of scope

Marie- Christine Bielsky

Expert Medical Assessor, Medicines

& Healthcare

Products Regulatory Agency

N/A None N/A

Dr Daniel Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

I have given several webinars recently for Thrombosis UK and published several blog posts on an open access medical education platform

https://www.letstalkclots.com/

January 2020 – October 2020

Declare and participate.

(2)

organisation interest dates https://www.stemlynsblog.org/vte-and-covid-19-would-you-like-

to-know-more/

Declaration is sufficient mitigation.

Dr Daniel Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

I am co-chief investigator for an active NIHR HTA research project looking at the clinical and cost effectiveness of venous thromboembolism risk assessment tools.

June 2019 – ongoing

Declare and participate.

Interest is non- specific.

Dr Daniel

Horner Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

I was a topic expert for NG 158 Sept 2018

– March 2020

Declare and participate.

Dr Daniel Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

I was a topic expert for the recent British Thoracic Society guidelines on the outpatient management of suspected or confirmed pulmonary embolism

August 2017 – August 2019

Declare and participate.

Interest is non- specific Dr Daniel

Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

I am a current Professor of the Royal College of Emergency Medicine. This is an unfunded nominal post.

October 2017 - ongoing

Declare and participate.

Interest is non- specific

(3)

organisation interest dates Dr Daniel

Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

I have written several blog articles on the use of tocilizumab in COVID19 for a free open access medical education website – the links to all three are within the below:

https://www.stemlynsblog.org/tocilizumabulous-a-special-offer- on-il-6-with-tocilizumab/

February 2021

Declare and participate.

Open declaration is sufficient mitigation.

Interest is out of scope

Dr Daniel Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

BMJ editorial on target oxygen saturations for acutely ill medical patients:

https://www.bmj.com/content/363/bmj.k4436

2018 Declare and participate.

Interest is non- specific Dr Daniel

Horner

Consultant in Emergency and Critical Care Medicine, Salford Royal NHS Foundation Trust

Non- financial professional and

personal

Written an open access blog article during the early discussions on VITT. This site is a free educational resource without funding or obligation.

https://www.stemlynsblog.org/post-vaccine-headache-in-the- emergency-department-what-you-need-to-know-st-emlyns/

April 2021 Declare and participate.

Open declaration is sufficient mitigation.

Prof Beverley Hunt

Professor/Consultant - Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust

Non- financial professional and

personal

Member of WHO COVID-19 guidance development group Date not provided

Declare and participate.

Interest is non- specific

(4)

organisation interest dates Prof

Beverley Hunt

Professor/Consultant - Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust

Direct-non- financial

Medical Director of Thrombosis UK 2002 –

present

Declare and participate.

Interest is non- specific Prof

Beverley Hunt

Professor/Consultant - Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust

Non- financial professional and

personal

Chair of the steering group of World Thrombosis Day 2019 - ongoing

Declare and participate.

Interest is non- specific Prof

Beverley Hunt

Professor/Consultant - Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust

Non- financial professional and

personal

I sit on the COVID-19 therapeutic anticoagulation therapy domain governance committee of REMAP-CAP.

2020 - present

Declare and participate.

Open declaration is sufficient mitigation as member acts in a governance role only.

Prof Beverley Hunt

Professor/Consultant - Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust

Non- financial professional and

personal

Member of the thrombostasis subcommittee of UK COVID-19 experimental treatment group

2020 – present

Declare and participate.

Open declaration is sufficient mitigation.

(5)

organisation interest dates Prof

Beverley Hunt

Professor/Consultant - Thrombosis and Haemostasis, Guy's and St Thomas' NHS Foundation Trust

Non- financial professional and

personal

Author of BMJ Editorial:

Prophylactic anticoagulation for patients in hospital with covid- 19

BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.n487 (Published 19 February 2021) Cite this as: BMJ 2021;372:n487

February 2021

Declare and participate.

Open declaration is sufficient mitigation

Interest is out of scope

Dr Will Lester

Haematology Consultant,

University Hospitals Birmingham NHS Trust

Direct, financial

Have attended advisory boards for pharmaceutical companies in the past with one off honorariums, none have attended within the last 12 months or been in relation to COVID-19/VITT.

Have received speaker honorariums from pharmaceutical companies that market DOACS - Bayer, Boehringer Ingelheim, Bristol Meyers Squibb, Daiichi Sankyo, Pfizer. No presentations in relation to VITT

2011 – ongoing

Declare and participate.

Open declaration is sufficient mitigation, as none in last 12 months related to VITT.

Dr Will Lester

Haematology Consultant,

University Hospitals Birmingham NHS Trust

Direct, financial

Speaker fees from Leo pharma who manufacture Tinzaparin in 2019

2019 Declare and participate.

Open declaration is sufficient mitigation, as Tinzaparin is not recommended in guideline.

(6)

organisation interest dates Prof

Michael Makris

Professor of Haemostasis and Thrombosis, University of Sheffield

Indirect financial

I am the project lead for the European Haemophilia Safety Surveillance system (EUHASS). This was set up in 2008 and was initially funded by the European Commission. It is now funded equally by 12 pharmaceutical companies and one of these is Pfizer, the maker of a COVID-19 vaccine. During 2008- 2021 EUHASS has been run from the University of Sheffield but from 1st January 2022 it will be run by the European Association for Haemophilia and Allied Disorders (EAHAD).

2008 – ongoing

Declare and participate.

Open declaration is sufficient mitigation - employer

receives funding Prof

Michael Makris

Professor of Haemostasis and Thrombosis, University of Sheffield

Non- financial professional and

personal

Member of the Expert Haematology Group since 22nd March 2021 set up to discuss Vaccine-induced Immune

Thrombocytopenia with Thrombosis

March 2021 – ongoing

Declare and participate

Dr Sue

Pavord Consultant Haematologist, Oxford University Hospitals NHS Foundation Trust

N/A None N/A

Gary Peters

Medical Assessor, Medicines &

Healthcare Products Regulatory Agency

N/A None N/A

Simon Race

Lay member N/A None N/A

Stacey Ridpath

Lay member N/A None N/A

(7)

organisation interest dates Prof Marie

Scully

Consultant Haematologist, University College London Hospitals

Direct, financial

Advisory board and speakers’ fees for Sanofi, Takeda and Octa pharma, the advice and presentations were in specific to

Thrombotic Thrombocytopenic Purpura.

I have advised Novartis board exclusively on Idiopathic thrombocytopenic Purpura and eltrombopag.

None of these interests have been in relation to COVID-19, vaccine related or VITT

January 2018 – ongoing

Declare and participate.

The interest is not specific to the scope of the guideline. Open declaration is sufficient

mitigation and will be kept under review for subsequent updates Prof Marie

Scully

Consultant Haematologist, University College London Hospitals

Direct, financial

Grants from Shire and Novartis not related to COVID-19 and VTE/heparins

June 2017 – ongoing

Declare and participate.

Interest is non- specific

Open declaration is sufficient mitigation Prof Marie

Scully

Consultant Haematologist, University College London Hospitals

Non- financial professional and

personal

Clinical lead UK TTP forum and TTP network 2015 – ongoing

Declare and participate.

Interest is non- specific

(8)

organisation interest dates Prof Marie

Scully

Consultant Haematologist, University College London Hospitals NHS

Non- financial professional and

personal

Professor of haemostasis and thrombosis, University College London

2018 – ongoing

Declare and participate.

Prof Marie Scully

Consultant Haematologist, University College London Hospitals

Non- financial professional and

personal

CI for recombinant ADAMTS13 phase two and phase three studies not relevant to COVID-19 or VTE

2017 – ongoing

Declare and participate.

Interest is non- specific

Prof Marie Scully

Consultant Haematologist, University College London Hospitals

Indirect COVID 19 thrombo prophylaxis guidance, expert advisor for NICE

June 2020 – ongoing

Declare and participate.

Interest is non- specific

Prof Marie Scully

Consultant Haematologist, University College London Hospitals

Indirect Caplacuzimab - NICE expert advisor 2018 -

2020

Declare and participate.

Interest is non- specific

Dr Waqaar

Shah General Practitioner, Chatfield Health Care

Direct –

financial GP partner at Chatfield Health Care 3UJ. This is an NHS GP practice, and my scope of work is that of a standard GP. I do not see private patients.

Ongoing Declare and participate Interest is non- specific

(9)

organisation interest dates Dr Waqaar

Shah

General Practitioner, Chatfield Health Care

Non- financial professional and

personal

Clinical lead at South West London CCG, representing GP practices in my locality, and co-chairing the Ophthalmology network. I occasionally represent the Royal College of GPs in respect of eye matters, such as attending meetings at the Clinical Council for Eye Health Commissioning. I don’t undertake any work related to COVID19.

Ongoing Declare and participate Interest is non- specific

Dr Waqaar

Shah General Practitioner, Chatfield Health Care

Non- financial professional and

personal

Has written numerous articles on post COVID syndrome Ongoing Declare and participate

Interest is out of scope

Malcolm Qualie (Non-voting member on panel)

NHS England

Representative/Topic Adviser

Non- financial professional and

personal

NHSE/I have published several policies relating to COVID -19 relating to service provision and therapeutic treatments – see https://www.england.nhs.uk/coronavirus/ for overarching recommendations and

https://www.england.nhs.uk/coronavirus/clinical-policy/ for specific policies

March 2020 – ongoing

Declare and participate.

Rationale:

Member is acting in an advisory capacity and is a non-voting member.

Organisational interest declared on behalf of NHS England in the interests of transparency.

(10)

organisation interest dates Astrid

Ullrich- Boereboom

Lay member N/A None N/A

References

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