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Anti-tuberculosis drugs sensitivity of BCG pasture strain isolated from lymphadenitis of children after vaccination by BCG vaccine

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73

ﺳرﺮﺑ

ﺮﺛا

ﯽﺘﻇﺎﻔﺣ

هرﺎﺼﻋ

ﯽﻠﮑﻟاورﺪﯿﻫ

ﺶﺨﺑ

ﺎﻫ

ي

اﻮﻫ

ﯽﯾ

هﺎﯿﮔ

ﺟﺎﻬﻟا

مورورﻮﺋﺎﻣ

رد

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ﺴﮐﻮﺗوﺮﻔﻧ

ﯿ

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دﺎﺣ

ءﺎﻘﻟا

هﺪﺷ

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ﻪﻄﺳاو

ﺎﻣﺎﺘﻨﺟ

ﯿ

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اﺮﺤﺻ

ﯽﯾ

ﻪﻤﻃﺎﻓ ﯾ ﺑﻮﻘﻌ ﯿ نﺎ 1 ، داﻮﺟ ﻏاﺮﭼ ﯽ 2  ، ﻣﯿ ﻮﻨ دﻮﻤﺤﻣ ي 3 1 ( هوﺮﮔ يرﻮﻧﺎﺟ يژﻮﻟﻮﯾﺰﯿﻓ ، دازآ هﺎﮕﺸﻧاد ﯽﻣﻼﺳا ناﺪﻤﻫ 2( ﺮﯿﭘ هﺪﮑﺸﻧاد مادا ،ﯽﮑﺷﺰﭘ مﻼﯾا هﺎﮕﺸﻧاد 3 ( ﯽﺳﺎﻨﺷ ﺖﺴﯾز هوﺮﮔ ، مﻮﻠﻋ هﺪﮑﺸﻧاد ، دازآ هﺎﮕﺸﻧاد ﯽﻣﻼﺳا ناﺪﻤﻫ ﺖﻓﺎﯾرد ﺦﯾرﺎﺗ : 29 /2 / 92 شﺮﯾﺬﭘ ﺦﯾرﺎﺗ : 22 /7 / 92 ژاو يﺎﻫ ه ﻠﮐ ﯿ ي : ﺟﺎﻬﻟا ﯽ ،مورورﻮﺋﺎﻣ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ،ﻦ ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ * لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ : مﻼﯾا هﺎﮕﺸﻧاد ،ﯽﮑﺷﺰﭘ ماداﺮﯿﭘ هﺪﮑﺸﻧاد Email: J.cheraghi@Ilam.ac.ir ﮑﭼ ﯿ هﺪ ﻪﻣﺪﻘﻣ : مﺮﮔ يﺎﻫ يﺮﺘﮐﺎﺑ زا ﻞﺻﺎﺣ ﺖﻧﻮﻔﻋ نﺎﻣرد رد ﻪﮐ ﺖﺳا يﺪﯾزﻮﮑﯿﻠﮔ ﻮﻨﯿﻣآ يﺎﻫ ﮏﯿﺗﻮﯿﺑ ﯽﺘﻧآ ،ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﯽﻣ هدﺎﻔﺘﺳا ﯽﻔﻨﻣ دﻮﺷ . ﺎﺑ دﻮﺟو رﺎﺛآ نﺎﺸﺧرد ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ رد نﺎﻣرد تﻼﮑﺸﻣ ﻠﮐ ﯿﻮ ي ، ﺑ ﻪ ﺮﻃﺎﺧ رﺎﺛآ ﺒﻧﺎﺟ ﯽ هدﺎﻔﺘﺳا زا نآ ﺎﺑ ﻣ دوﺪﺤ ﯾ ﺖ ور ﺑ ﻪ ور ا ﺖﺳ . ﻧﺎﮐ ﯽﯾوراد نﺎﻫﺎﯿﮔ رد دﻮﺟﻮﻣ ﯽﻧاﺪﯿﺴﮐا ﯽﺘﻧآ تﺎﺒﯿﮐﺮﺗ ﺪ يﺮﯿﮕﺸﯿﭘ و ﺖﻇﺎﻔﺣ ياﺮﺑ ﯽﺒﺳﺎﻨﻣ ياﺪﯾ ﺪﻧﻮﺷ ﯽﻣ بﻮﺴﺤﻣ يراردا هﺎﮕﺘﺳد ﺮﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﮏﯾژﻮﻟﻮﺗﺎﭘ تاﺮﺛا زا . در ﻖﯿﻘﺤﺗ ﺮﺿﺎﺣ ياﺮﺑ ﻦﯿﻟوا رﺎﺑ ﺮﺛا ﯽﺘﻇﺎﻔﺣ هرﺎﺼﻋ ﯽﯾاﻮﻫ يﺎﻫ ﺶﺨﺑ ﯽﻠﮑﻟاورﺪﯿﻫ هﺎﯿﮔ ﺟﺎﻬﻟا ﯽ رورﻮﺋﺎﻣ مو ) ﺮﺘﺷرﺎﺧ ( ﺎﺑ ﻪﻠﺑﺎﻘﻣ ﺖﻬﺟ ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ ﯽﺷﺎﻧ زا ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ رد شﻮﻣ ﯽﯾاﺮﺤﺻ درﻮﻣ ﯽﺑﺎﯾزرا راﺮﻗ ﺖﻓﺮﮔ . داﻮﻣ و شور ﺎﻫ : 28 رﺎﺘﺴﯾو داﮋﻧ ﺮﻧ ﯽﯾاﺮﺤﺻ شﻮﻣ ﺮﺳ ) ﯽﻧزو هدوﺪﺤﻣ 20 ± 300 مﺮﮔ (ﺑ ﻪ رﻮﻃ ﯽﻓدﺎﺼﺗ ﺑﻪ 4 هوﺮﮔ )7 (n= ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ . هوﺮﮔ 1 : لﺮﺘﻨﮐ هوﺮﮔ ) Ctrl ( هوﺮﮔ ، 2 : هﺪﻨﻨﮐ ﺖﻓﺎﯾرد هرﺎﺼﻋ ) Ext ( هوﺮﮔ ، 3 : هﺪﻨﻨﮐ ﺖﻓﺎﯾرد ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ) G ( هوﺮﮔ و ، 4 : ﯽﻫﺎﯿﮔ هرﺎﺼﻋ هاﺮﻤﻫ ﻪﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﻪﮐ ﯽﻫوﺮﮔ ) G+Ext ( دﻮﻤﻧ ﺖﻓﺎﯾرد . ﺖﺤﺗ يﺎﻫ شﻮﻣ تﺪﻣ ﻪﺑ ﺶﯾﺎﻣزآ 8 ﺪﻧدﺮﮐ ﺖﻓﺎﯾرد ار ﺮﻈﻧ درﻮﻣ تﺎﺒﯿﮐﺮﺗ ﯽﻣﺎﻤﺗ زور . ﺮﺧآ زور رد ﻪﻧﻮﻤﻧ ﺎﻫ ي ﻧﻮﺧ ﯽ ﻬﺗ ﯿﻪ ﺖﻈﻠﻏ و ﻣﺮﺳ ﯽ اﺮﮐ ،هروا يﺎﻫﺮﺘﻣارﺎﭘ نﻮﺧ هروا تزا ،ﻦﯿﻨﯿﺗ ) BUN ( ﺖﻓﺮﮔ راﺮﻗ ﺶﺠﻨﺳ درﻮﻣ ﮏﯾروا ﺪﯿﺳا و . ﻪﺘﻓﺎﯾ ﺶﻫوﮋﭘ يﺎﻫ : يراد ﯽﻨﻌﻣ رﻮﻃ ﻪﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ) P<0.05 ( ،هروا يﺎﻫ ﺖﻈﻠﻏ ﺶﯾاﺰﻓا ﺐﺟﻮﻣ BUN ، ﺪﯾدﺮﮔ ﺶﯾﺎﻣزآ ﺖﺤﺗ ﯽﯾاﺮﺤﺻ يﺎﻫ شﻮﻣ نﻮﺧﺪﯿﺳا ﮏﯾروا و ﻦﯿﻨﯿﺗاﺮﮐ . ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ مأﻮﺗ ﻖﯾرﺰﺗ + ﺮﺘﺷرﺎﺧ هﺎﯿﮔ هرﺎﺼﻋ ﺪﻌﺗ ﺐﺟﻮﻣ ﺪﯾدﺮﮔ دﻮﺧ لﺎﻣﺮﻧ حﻮﻄﺳ ﻪﺑ يﻮﯿﻠﮐ دﺮﮑﻠﻤﻋ يﺎﻫﺮﮐرﺎﻣ ﻪﺘﻓﺎﯾ ﺶﯾاﺰﻓا ﺮﯾدﺎﻘﻣ ﻞﯾ . ﺚﺤﺑ و ﺘﻧ ﯿ ﻪﺠ ﯿ ي : ﻪﮐ داد نﺎﺸﻧ ﻪﻌﻟﺎﻄﻣ ﻦﯾا ﺞﯾﺎﺘﻧ هرﺎﺼﻋ ﯽﻠﮑﻟاورﺪﯿﻫ هﺎﯿﮔ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ ) ﺮﺘﺷرﺎﺧ ( ﺖﺳا ردﺎﻗ ﺪﯾﺎﻤﻧ يﺮﯿﮕﺸﯿﭘ يراردا ﻢﺘﺴﯿﺳ ﺮﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﯽﺒﻧﺎﺟ تاﺮﺛا زا يﺮﺛﺆﻣ رﻮﻃ ﻪﺑ . ﻪﺠﯿﺘﻧ رد ﻪﯿﻬﺗ زا ﺲﭘ دور ﯽﻣ لﺎﻤﺘﺣا دﺮﺑ رﺎﮐ ﻪﺑ ﺎﻫ ﻪﯿﻠﮐ زا ﺖﻇﺎﻔﺣ ﺖﻬﺟ ﯽﻌﯿﺒﻃ يوراد ناﻮﻨﻋ ﻪﺑ ار نآ ناﻮﺘﺑ ،ﺮﺘﺷرﺎﺧ هﺎﯿﮔ هﺮﺛﺆﻣ تﺎﺒﯿﮐﺮﺗ ﯽﺗرﺎﺠﺗ .

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74 ﻘﻣ ﻪﻣﺪ يرﺎﯿﺴﺑ زا ﺎﻫوراد و ﺎﯾ داﻮﻣ ﯽﯾﺎﯿﻤﯿﺷ دﻮﺟﻮﻣ رد ﻂﯿﺤﻣ ﺐﺟﻮﻣ ﺖﯿﻣﻮﻤﺴﻣ و ﺑ ﻪ لﺎﺒﻧد نآ ﺐﯿﺳآ ﯽﺘﻓﺎﺑ ﻪﯿﻠﮐ ﺎﻫ هﺪﺷ ﻪﮐ رد ﺖﯾﺎﻬﻧ ﺐﺟﻮﻣ ﯽﯾﺎﺳرﺎﻧ يﻮﯿﻠﮐ ﯽﻣ ددﺮﮔ . ﺐﯾﺮﺨﺗ ﻮﻠﺳ ل يﺎﻫ ﯽﺸﺷﻮﭘ لﻮﺑﻮﺗ ﺎﻫ ﺎﯾ زوﺮﮑﻧ ﯽﻟﻮﺑﻮﺗ ﯽﮑﯾ زا ﻞﻠﻋ دﺎﺠﯾا ﯽﯾﺎﺳرﺎﻧ دﺎﺣ يﻮﯿﻠﮐ ﺖﺳا . زا ﻢﻬﻣ ﻦﯾﺮﺗ اﻮﻋ ﻞﻣ دﺎﺠﯾا زوﺮﮑﻧ ﯽﻟﻮﺑﻮﺗ ﯽﻣ ناﻮﺗ ﻪﺑ ﺶﻫﺎﮐ ﺪﯾﺪﺷ نﺎﯾﺮﺟ نﻮﺧ و ﺖﯿﻣﻮﻤﺴﻣ ﯽﺷﺎﻧ زا فﺮﺼﻣ يﺎﻫوراد ﯽﯾﺎﯿﻤﯿﺷ هرﺎﺷا دﺮﮐ . ﺖﺳﺮﻬﻓ يﺪﻨﻠﺑ زا عاﻮﻧا مﻮﻤﺳ و ﺎﻫوراد دﻮﺟو دراد ﻪﮐ ﯽﻣ ﺪﻨﻧاﻮﺗ ﻪﺑ لﻮﻠﺳ يﺎﻫ ﯽﻟﻮﺑﻮﺗ ﺐﯿﺳآ هﺪﻧﺎﺳر و زا ﻦﯾا ﻖﯾﺮﻃ ﺐﺟﻮﻣ ﯽﯾﺎﺳرﺎﻧ يﻮﯿﻠﮐ دﺎﺣ ﺪﻧﻮﺷ ). 1( ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﮏﯿﺗﻮﺑ ﯽﺘﻧآ ﻪﺘﺳد زا ﻊﯿﺳو يﺎﻫ ﻒﯿﻄﻟا ﺖﻧﻮﻔﻋ ﺎﺑ ﻪﻠﺑﺎﻘﻣ ﺖﻬﺟ ﻪﮐ ﺖﺳا يﺪﯾزﻮﮑﯿﻠﮔﻮﻨﯿﻣآ ﯽﺷﺎﻧ يﺎﻫ يﺮﺘﮐﺎﺑ زا سﻮﺌﺗوﺮﭘ ،سﺎﻧﻮﻣودﻮﺳ ﻞﯿﺒﻗ زا ﯽﻔﻨﻣ مﺮﮔ يﺎﻫ و ... ﯽﻣ راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ دﺮﯿﮔ ،) 2 .( و دراﻮﻣ يرﺎﯿﺴﺑ رد ﯽﺘﺣ ﯽﺘﻧآ ﺮﯾﺎﺳ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﮏﯿﺗﻮﯿﺑ ﯽﯾﺎﯾﺮﺘﮐﺎﺑ ﺖﻣوﺎﻘﻣ ﻪﮐ ﺎﻫ ﺠﯾا ﯽﻣ دﺎ ﺎﻬﻨﺗ ،ﺪﻨﻨﮐ ﯽﺘﻧآ ﯽﻣ بﺎﺴﺣ ﻪﺑ ﺮﺛﺆﻣ ﮏﯿﺗﻮﯿﺑ ﺪﯾآ ). 3( ﺎﻫوراد زا قﺮﻃ ﻒﻠﺘﺨﻣ زا ﻪﻠﻤﺟ ﻪﻣﺪﺻ ﻘﺘﺴﻣ ﯿ ﻢ ﻗوﺮﻋ ﯽ ، بﺎﻬﺘﻟا آ ،ﮏﯾژﺮﻟ آ ﺳ ﯿ ﺐ ﺎﺸﻏ ي ﺎﭘ ﯾﻪ ﻟوﺮﻣﻮﻠﮔ ﯽ ﺐﺒﺳ اﯾ دﺎﺠ ﺎﺳرﺎﻧ ﯽﯾ ﺣ ﺎد ﻠﮐ ﯿﻮ ي ﻣ ﯽ ﺪﻧﻮﺷ . ﺧﺮﺑ ﯽ زا ﺎﻫوراد ﻧﯿ ﺰ ﺎﺑ ﺛﺎﺗ ﯿﺮ ﺮﺑ ﻧﺎﮑﻣ ﯿ ﻢﺴ ﺎﻫ ي ﺎﭘ ﯾﻪ ﮑﺸﺗ ﯿ ﻞ راردا ﺐﺒﺳ دوﺪﺤﻣ ﯾ ﺖ رﺎﮐ ﻠﮐ ﯿﻪ ﺎﻫ ﻣ ﯽ ﺪﻧدﺮﮔ . اﺰﻓا ﯾ ﺶ BUN و ﺗاﺮﮐ ﯿﻨ ﯿ ﻦ مﺮﺳ ﻢﺋﻼﻋ زا ﯽﻧوﺮﻔﻧ ﺐﯿﺳآ ﺑ هدﻮ ﻪﮐ ﺐﻠﻏا ﻪﺑ لﺎﺒﻧد لﻼﺘﺧا رد ﻓ ﯿ ﺳاﺮﺘﻠ ﯿ نﻮ ﯽﻟوﺮﻣﻮﻠﮔ خر ﻣ ﯽ ﺪﻫد . ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﯽﮑﯾ زا ﻞﻠﻋ ﻊﯾﺎﺷ ﯽﯾﺎﺳرﺎﻧ دﺎﺣ يﻮﯿﻠﮐ ﯽﻣ ﺪﺷﺎﺑ و يﺪﻫاﻮﺷ ﯽﻨﺒﻣ ﺮﺑ دﺎﺠﯾا ،زوﺮﮑﻧ ،ﺲﯾزﻮﺘﭘﻮﭘآ ،ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا ﺗوﺪﻧا ﺶﯾاﺰﻓا ﻦﯿﻠ -1 ، ﺖﯿﺳﻮﻧﻮﻣ ﺶﯾﻻﺎﭘ نورد ﺶﯾاﺰﻓا / ﺎﻫژﺎﻓوﺮﮐﺎﻣ ،) 8 -4( ، و ﻪﻧﻮﮔ ﺪﯿﻟﻮﺗ ﺶﯾاﺰﻓا ﺶﻨﮐاو يﺎﻫ نﮋﯿﺴﮐا ﺮﯾﺬﭘ Reactive Oxygen Species ) ROS (،) 9( لﺎﮑﯾدار ، يﺎﻫ ﻪﻧﻮﮔ و نژورﺪﯿﻫ ﺪﯿﺴﮐاﺮﭘ ،ﻞﯿﺴﮐورﺪﯿﻫ ﺮﯾﺬﭘ ﺶﻨﮐاو يﺎﻫ نژوﺮﺘﯿﻧ

Reactive Nitrogen Species

) RNS ( ﻂﺳﻮﺗ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ راد دﻮﺟو د ﮐ رد ﻪﮐ ﻪﯿﻠ ﯽﺘﻓﺎﺑ ﺐﯿﺳآ ﺐﺟﻮﻣ ﺎﻫ ﯽﻣ ﺪﻧدﺮﮔ .) 10 ( ﺮﺑ ،ﺎﻫ شراﺰﮔ ﯽﺧﺮﺑ سﺎﺳا رد ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ ﺷﺎﻧ ﯽ ﺶﯾاﺰﻓا ،ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ زا BUN ،) 11،12 ( ، ﻦﯿﻨﯿﺗاﺮﮐ و مﺮﺳ ،) 13 -11 ( هروا ، ،) 13 ( ، اﺰﯿﻣ ﺶﻫﺎﮐ و ﯽﻟوﺮﻣﻮﻠﮔ ﻪﯿﻔﺼﺗ ن هﺪﺷ هﺪﻫﺎﺸﻣ ﺖﺳا .) 14 ( رد ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﻞﻤﻋ ﻢﺴﯿﻧﺎﮑﻣ نﻮﻨﮐﺎﺗ دﺎﺠﯾا ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ هﺪﺸﻧ ﻪﺘﺧﺎﻨﺷ ﻸﻣﺎﮐ ﺖﺳا . ﺑ دﻮﺟو ﻦﯾا ﺎﺑ ﻪ ﯽﻣ ﺮﻈﻧ ﺐﯿﺳآ ﻪﮐ ﺪﺳر ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﯽﺳﺎﻨﺷ ﻪﯿﻠﮐ رد ﺎﻫ زا لﺎﮑﯾدار ﺪﯿﻟﻮﺗ ﻖﯾﺮﻃ دازآ يﺎﻫ يﺪﯿﭙﯿﻟ نﻮﯿﺳاﺪﯿﺴﮐاﺮﭘ ، ،) 15 (، ﻪﯿﻠﮐ يﺮﺸﻗ ﺶﺨﺑ رد ﯽﻨﯿﺌﺗوﺮﭘ نﻮﯿﺳاﺪﯿﺴﮐاﺮﭘ و ،) 16 (، ﻞﺑﺎﻗ ﺪﺷﺎﺑ ﻪﯿﺟﻮﺗ . شراﺰﮔ سﺎﺳا ﺮﺑ ﺎﻣﺎﺘﻨﺟ ،ﺎﻫ ﻦﯿﺴﯾ ﺖﺳا ردﺎﻗ ﺎﺑ ﺶﻫﺎﮐ نداد ﺖﯿﻠﺑﺎﻗ ﺖﯿﻟﺎﻌﻓ و آ ﻢﯾﺰﻧ زا ناﺪﯿﺴﮐا ﯽﺘﻧآ يﺎﻫ زﺎﺗﻮﻤﺳدﺪﯿﺴﮐاﺮﭘﻮﺳ ﻪﻠﻤﺟ ) SOD ( زﻻﺎﺗﺎﮐ ، ) CAT ( ، نﻮﯿﺗﺎﺗﻮﻠﮔ زاﺪﯿﺴﮐاﺮﭘ ) GPX ( نﻮﯿﺗﺎﺗﻮﻠﮔ و ) GSH ( رد ﻪﯿﻠﮐ ، ﯽﺘﻓﺎﺑ ﺐﯾﺮﺨﺗ ﺐﺟﻮﻣ ار ددﺮﮔ ). 19 -17 ( ﯽﺧﺮﺑ زا تﺎﻌﻟﺎﻄﻣ نﺎﺸﻧ ﯽﻣ ﻫد ﺪ ﻪﮐ فﺮﺼﻣ ﯽﺘﻧآ ناﺪﯿﺴﮐا ﺎﻫ ﺐﺒﺳ ﺶﻫﺎﮐ ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ ﯽﺷﺎﻧ زا ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﯽﻣ ددﺮﮔ ،) 23 -20 .( ﺎﺑ ﮐ ﻒﺸ ﺘﻧآ ﯽ ﺴﮐا ﯿ ناﺪ ﺎﻫ رد ﺪﻨﭼ ﻪﻫد ﻪﺘﺷﺬﮔ ﻞﯾﺎﻤﺗ و ﺖﺳاﻮﺧ ﻪﻌﻣﺎﺟ ﯽﻧﺎﻬﺟ ﻪﺑ ﺖﻤﺳ هدﺎﻔﺘﺳا زا ﺐﻃ ﯽﺘﻨﺳ و نﺎﻫﺎﯿﮔ ﯽﯾوراد دﺎﯾز هﺪﺷ ﺖﺳا . نﺎﻨﭼ ﻪﭼ زا نﺎﻫﺎﯿﮔ هداﻮﻧﺎﺧ زﻮﻨﯿﻣﻮﮕﻟ (Leguminosae) نﻮﻨﮐﺎﺗ ﯽﻃ تﺎﻘﯿﻘﺤﺗ ﻪﺘﺷﺬﮔ هدﺎﻔﺘﺳا يﺎﻫ يدﺎﯾز هﺪﺷ ﺖﺳا و نﺎﺸﻧ هداد هﺪﺷ ﻪﮐ رد دﻮﺒﻬﺑ دﺮﮑﻠﻤﻋ ﻢﺘﺴﯿﺳ يﺎﻫ ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ نﺪﺑ ﺶﻘﻧ ﯽﻤﻬﻣ ﺪﻧراد . ﯽﮑﯾ زا نﺎﻫﺎﯿﮔ ﻦﯾا ،هداﻮﻧﺎﺧ هﺎﯿﮔ ﺮﺘﺷرﺎﺧ ﯽﻣ ﺪﺷﺎﺑ ، ﻪﮐ ﻪﺑ نﺎﺑز ﯽﻠﺤﻣ رد بﻮﻨﺟ و بﺮﻏ ناﺮﯾا و ﻪﻘﻄﻨﻣ سﺮﮔاز » لﻮﻗﺎﻋ « ﺎﯾ »آ و لﻮﮔ « هﺪﯿﻣﺎﻧ ﯽﻣ دﻮﺷ . مﺎﻧ ﯽﻤﻠﻋ ﻦﯾا ،هﺎﯿﮔ Alhagi maurorum ﺖﺳا . رد ﺐﻃ ﯽﺘﻨﺳ زا ﻦﯾا هﺎﯿﮔ رد نﺎﻣرد تﻻﻼﺘﺧا ﯽﺷراﻮﮔ ًﺎﺻﻮﺼﺧ ﻢﺧز هﺪﻌﻣ و ﻢﺴﯿﺗﺎﻣور هدﺎﻔﺘﺳا ﯽﻣ دﻮﺷ ،) 24،25 (، تﺎﻌﻟﺎﻄﻣ ﯽﻤﯿﺷ ﯽﻫﺎﯿﮔ ترﻮﺻ ﻪﺘﻓﺮﮔ ﺮﺑ يور ﻦﯾا ،هﺎﯿﮔ دﻮﺟو لوﺮﺘﺳا يﺎﻫ عﺎﺒﺷاﺮﯿﻏ ، يﺮﺗ ﻦﭘﺮﺗ ﺎﻫ ) (triterepens ، ﻦﻧﺎﺗ ﺎﻫ (tannins) ، تارﺪﯿﻫﻮﺑﺮﮐ ﻫ ،ﺎ ﺎﻫﺪﯿﺋﻮﻧوﻼﻓ ،) flavonoids (،) 26،27 (، يﺎﻫﺪﯾزﻮﮑﯿﻠﮔ نﻮﻧاوﻼﻓ ،) 27 (، زا ﻞﯿﺒﻗ ﻦﯾﺪﯿﺟﺎﻬﻟا ) Alhagidin ( و ﻦﯿﺘﯿﺟﺎﻬﻟا ) Alhagitin ( و ﻦﯿﻧﺎﯿﺳﻮﺘﻧآوﺮﭘ و ﻦﯾزر ﺎﻫ ار هﺪﻧﺎﺳر تﺎﺒﺛا ﻪﺑ ﺖﺳا ،) 28 ( . تﺎﻌﻟﺎﻄﻣ ز ﯾ دﺎ ي نﺎﺸﻧ داد ﻪﮐ يﺎﻫﺪﯿﺋﻮﻧوﻼﻓ دﻮﺟﻮﻣ رد هﺎﯿﮔ ﺮﺘﺷرﺎﺧ ﻦﯿﺘﺳﺮﺋﻮﮐ (Quercetin) و ﮐ ﻦﯿﺸﺗﺎ (Catechin) ﯽﻣ ﺪﻨﺷﺎﺑ ﻪﮐ ياراد ﺖﯿﻟﺎﻌﻓ ﯽﺘﻧآ ناﺪﯿﺴﮐا ﺪﻨﺘﺴﻫ .) 29 ( ﺎﻨﺑ ﺮﺑ ﻦﯾا ﺎﺑ ﻪﺟﻮﺗ ﻪﺑ تاﺮﺛا ﻒﻠﺘﺨﻣ هﺎﯿﮔ ﺮﺘﺷرﺎﺧ ﻪﺑ ﺖﻠﻋ دﻮﺟو تﺎﺒﯿﮐﺮﺗ ﯽﺘﻧآ ناﺪﯿﺴﮐا و ﻦﯿﺸﺗﺎﮐ و ... ﻪﮐ ﺮﻫ ماﺪﮐ ﺶﻘﻧ صﺎﺧ دﻮﺧ ار ﺪﻧراد ﻦﯾا ﻖﯿﻘﺤﺗ رد ﺮﻈﻧ دراد ﺎﺑ ﺰﯾﻮﺠﺗ هرﺎﺼﻋ هﺎﯿﮔ ﺮﺘﺷرﺎﺧ رد شﻮﻣ ﺤﺻ ،ﯽﯾاﺮ ﺖﯿﻟﺎﻌﻓ ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ ﻪﯿﻠﮐ ﺎﻫ ار ﯽﺳرﺮﺑ ﺪﯾﺎﻤﻧ . رد ترﻮﺻ ﺮﺛﺆﻣ ﻊﻗاو نﺪﺷ هرﺎﺼﻋ ﯽﻫﺎﯿﮔ درﻮﻣ ﺮﻈﻧ و تاﺮﺛا يﺮﯿﮕﺸﯿﭘ هﺪﻨﻨﮐ ،نآ ﺪﯾﺎﺷ ناﻮﺘﺑ نآ ار ﻪﺑ ناﻮﻨﻋ ﮏﯾ ﻞﻣﺎﻋ ﺮﺛﺆﻣ رد ﺶﻫﺎﮐ نداد ﺐﯿﺳآ يﺎﻫ ﻢﺘﺴﯿﺳ ﻮﯿﻠﮐ ي وراد ﯽﺒﻧﺎﺟ تاﺮﺛا زا ﯽﺷﺎﻧ ﺎﻫ ﯽﻓﺮﻌﻣ دﻮﻤﻧ . داﻮﻣ و شور ﺎﻫ ياﺮﺑ مﺎﺠﻧا ﻖﯿﻘﺤﺗ ﺮﺿﺎﺣ رد ﻞﺼﻓ رﺎﻬﺑ هﺎﯿﮔ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ زا ﻪﻨﻣاد هﻮﮐ يﺎﻫ نﺎﺘﺳا مﻼﯾا ﻊﻤﺟ يروآ ﺪﺷ .

(3)

75 ﺲﭘ زا ﯽﯾﺎﺳﺎﻨﺷ و ﺪﯿﯾﺄﺗ هﺎﯿﮔ ﻂﺳﻮﺗ نﺎﺳﺎﻨﺷرﺎﮐ دﺎﻬﺟ ﯽﻫﺎﮕﺸﻧاد نﺎﺘﺳا مﻼﯾا ﺶﺨﺑ يﺎﻫ ﯽﯾاﻮﻫ هﺎﯿﮔ زا ﻪﺸﯾر اﺪﺟ و ﺲﭘ زا ﯽﺸﮑﺑآ ﺎﺑ بآ دﺮﺳ رد ﻪﯾﺎﺳ ﮏﺸﺧ ﺪﯾدﺮﮔ . ﺲﭙﺳ ﻂﺳﻮﺗ بﺎﯿﺳآ ﯾا ﻦ ﺶﺨﺑ ﺎﻫ ار ﻪﺑ ترﻮﺻ ردﻮﭘ رد هدروآ و زا ردﻮﭘ ﻪﻠﺻﺎﺣ ياﺮﺑ ﻪﯿﻬﺗ هرﺎﺼﻋ هدﺎﻔﺘﺳا ﺪﺷ . ،هﺎﯿﮔ ﯽﻠﮑﻟاورﺪﯿﻫ هرﺎﺼﻋ ﻪﯿﻬﺗ ياﺮﺑ ﺮﻫ 50 مﺮﮔ ردﻮﭘ هﺎﯿﮔ ﺮﺘﺷرﺎﺧ ﻪﺑ ار 800 ﯽﻠﯿﻣ ﺮﺘﯿﻟ ﻞﮑﻟا ﮏﯿﻠﯿﺗا 50 ﺪﺻرد ﻪﻓﺎﺿا هدﺮﮐ و لﻮﻠﺤﻣ ﻪﻠﺻﺎﺣ ﻪﺑ تﺪﻣ 48 ﺖﻋﺎﺳ رد هﺎﮕﺘﺳد ﻪﻠﺴﮐﻮﺳ راﺮﻗ هداد ﺪﺷ . ﺲﭙﺳ ﺼﻋ هرﺎ ﺑ ﻪ هﺪﻣآ ﺖﺳد ار رد ﺮﻓ ) نوآ ( 55 ﻪﺟرد ،ﻪﺘﺷاﺬﮔ ،لﻼﺣ ﺮﯿﺨﺒﺗ زا ﺲﭘ ﯽﻗﺎﺑ هدﺎﻣ ﺪﯾدﺮﮔ يروآ ﻊﻤﺟ ﺖﺳا ﺮﺘﺷ رﺎﺧ هﺎﯿﮔ هرﺎﺼﻋ ﻪﮐ هﺪﻧﺎﻣ . رد ﻦﯾا ﻖﯿﻘﺤﺗ 28 ﺮﺳ شﻮﻣ ﯽﯾاﺮﺤﺻ ﺮﻧ داﮋﻧ رﺎﺘﺴﯾو رد هدوﺪﺤﻣ و ﯽﻧز 20 ± 300 مﺮﮔ ﻪﮐ زا ﺣ ﯿ ناﻮ ﻪﻧﺎﺧ هﺪﮑﺸﻧاد اﺮﯿﭘ ماد ﯽﮑﺷﺰﭘ هﺎﮕﺸﻧاد مﻼﯾا ﻪﯿﻬﺗ هﺪﺷ ،دﻮﺑ هدﺎﻔﺘﺳا ﺪﺷ . تﺎﻧاﻮﯿﺣ ﻪﺑ تﺪﻣ ﮏﯾ ﻪﺘﻔﻫ رد ﻂﯾاﺮﺷ نﺎﺴﮑﯾ لﺮﺘﻨﮐ هﺪﺷ زا ﺮﻈﻧ ناﺰﯿﻣ رﻮﻧ ) 12 ﺖﻋﺎﺳ ﯽﯾﺎﻨﺷور / ﯽﮑﯾرﺎﺗ ﻪﺑ رﻮﻃ بوﺎﻨﺘﻣ ( و يﺎﻣد 20 داﺮﮔ ﯽﺘﻧﺎﺳ ﻪﺟرد ﻞﺧاد ﺲﻔﻗ رد هﺎﮕﺸﯾﺎﻣزآ ﯽﺗﺎﻘﯿﻘﺤﺗ هﺪﮑﺸﻧاد ماد ﯽﮑﺷﺰﭘ هﺎﮕﺸﻧاد مﻼﯾا ﻪﮕﻧ يراد ﺪﻧﺪﺷ . بآ و اﺬﻏ ﻪﺑ رﻮﻃ ﻪﻧادازآ رد ﺘﺧا رﺎﯿ تﺎﻧاﻮﯿﺣ راﺮﻗ هداد ﺪﺷ . ياﺬﻏ شﻮﻣ ﺎﻫ زا ﻪﻧﺎﺧرﺎﮐ كارﻮﺧ ماد ﺖﮐﺮﺷ ﻪﺑ روﺮﭘ جﺮﮐ ﻪﯿﻬﺗ ﺪﺷ . رد ﻦﯾا ﻖﯿﻘﺤﺗ زا مﺮﺳ ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ ) ﺖﮐﺮﺷ Nasr Foriman (، ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ) ﺖﮐﺮﺷ Tamin (، زود ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺮﺑ سﺎﺳا تﺎﻌﻟﺎﻄﻣ مﺎﺠﻧا هﺪﺷ ﻂﺳﻮﺗ ﻦﯾﺮﯾﺎﺳ mg/kg 10 بﺎﺨﺘﻧا ﺪﯾدﺮﮔ ،) 30 .( ﺖﻬﺟ ﯿﻬﺗ ﻪ ﻦﯾا زود mg 80 ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ رد 6 ﯽﻠﯿﻣ ﺮﺘﯿﻟ بآ ﺮﻄﻘﻣ ﻞﺣ ﺪﯾدﺮﮔ . ياﺮﺑ بﺎﺨﺘﻧا زود ﺮﺛﺆﻣ هرﺎﺼﻋ ﯽﻠﮑﻟاورﺪﯿﻫ هﺎﯿﮔ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ رد ﮏﯾ ﻪﻌﻟﺎﻄﻣ ﯽﺗﺎﻣﺪﻘﻣ زا ﻦﯿﺑ ﺞﻨﭘ زود 100 ، 200 ، 400 ، 600 و 800 ، زود ﺮﺛﻮﻣ mg/kg 400 ا بﺎﺨﺘﻧ ﺪﯾدﺮﮔ ياﺮﺑ ﻪﯿﻬﺗ ﻦﯾا زود 42 مﺮﮔ زا ردﻮﭘ ﻪﯿﻬﺗ ﺪﺷ ه زا ﺶﺨﺑ يﺎﻫ ﯽﯾاﻮﻫ هﺎﯿﮔ رد 175 ﯽﻠﯿﻣ ﺮﺘﯿﻟ مﺮﺳ ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ ﻞﺣ ﺪﯾدﺮﮔ . ﺑ ﺶﯾﺎﻣزآ درﻮﻣ تﺎﻧاﻮﯿﺣ مﺎﻤﺗ ﻪ ﻪﺑ ﯽﻓدﺎﺼﺗ رﻮﻃ 4 هوﺮﮔ ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ يرﺎﻤﯿﺗ . 1 -هوﺮﮔ لوا ﻪﺑ ناﻮﻨﻋ هوﺮﮔ لﺮﺘﻨﮐ ) هوﺮﮔ Ctrl ( 5/ 0 ﯽﻠﯿﻣ ﺮﺘﯿﻟ مﺮﺳ ﮏﯾژﻮﻟﻮﯾﺰﯿﻓ . 2 -ﻪﺑ رﻮﻈﻨﻣ دﺎﺠﯾا ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ ﻪﺑ هوﺮﮔ ود م ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ) هوﺮﮔ mg/kg (G 10 . 3 -هوﺮﮔ مﻮﺳ هﺪﻨﻨﮐ ﺖﻓﺎﯾرد هرﺎﺼﻋ ) هوﺮﮔ Ext .( 4 -ياﺮﺑ ﯽﺑﺎﯾزرا ﺮﺛا ﯽﺘﻇﺎﻔﺣ هرﺎﺼﻋ هﺎﯿﮔ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ ﻪﺑ هوﺮﮔ ﺎﯾ مرﺎﻬﭼ هوﺮﮔ يرﺎﻤﯿﺗ mg/kg 400 هرﺎﺼﻋ ﮔ ﯿ ﻫﺎ ﯽ ﺷرﺎﺧ ﺘﺮ ﺑ ﻪ هوﻼﻋ mg/kg 10 ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ) هوﺮﮔ Ext + G (، ﺪﯾدﺮﮔ ﺰﯾﻮﺠﺗ .) 15 ﻗد ﯿ ﻪﻘ ﻞﺒﻗ زا ﺗ ﻮﺠ ﯾﺰ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ،ﻦ ﺣ ﯿ تﺎﻧاﻮ اﯾ ﻦ هوﺮﮔ هرﺎﺼﻋ ﮔ ﯿ ﻫﺎ ﯽ رد ﯾ ﺖﻓﺎ ﻣ ﯽ ﺪﻧدﺮﮐ ( ﻞﺧاد ﻖﯾرﺰﺗ ترﻮﺻ ﻪﺑ ﺎﻫ لﻮﻠﺤﻣ و وراد ﺰﯾﻮﺠﺗ ﺖﻋﺎﺳ رد و ﯽﻗﺎﻔﺻ 12 ﺑ ،ﺮﻬﻇ ﻪ ﺖﻓﺮﮔ مﺎﺠﻧا ﻪﻧازور رﻮﻃ . ﻖﯾرﺰﺗ ﻢﺠﺣ 5/ 0 و ﺮﺘﯿﻟ ﯽﻠﯿﻣ ﺶﯾﺎﻣزآ مﺎﺠﻧا نﺎﻣز تﺪﻣ 8 ﺪﯿﺸﮐ ازارد ﻪﺑ ﯽﻟاﻮﺘﻣ زور . رد نﺎﯾﺎﭘ زور ﻢﺘﺸﻫ زا ﻧاﻮﯿﺣ تﺎ ﺪﻣآ ﻞﻤﻋ ﻪﺑ يﺮﯿﮔ نﻮﺧ . ﻪﺑ رﻮﻈﻨﻣ ﯽﺑﺎﯾزرا دﺮﮑﻠﻤﻋ ،ﻪﯿﻠﮐ ﺖﻈﻠﻏ ﯽﻣﺮﺳ هروا و BUN ﺎﺑ شور ﺮﺑ ،ﺖﻟﻮﺗ ﻦﯿﻨﯿﺗاﺮﮐ ﺎﺑ شور ﻪﻓاژ و ﮏﯾرواﺪﯿﺳا ﺎﺑ شور پﺎﭘ و ﺎﺑ هدﺎﻔﺘﺳا زا شور ﯽﺠﻨﺳرﻮﻧ ﻂﺳﻮﺗ هﺎﮕﺘﺳد ) ﺮﺘﻣﻮﺘﻓوﺮﺘﮑﭙﺳا Sinco ( ﻪﺑ ﮏﻤﮐ ﺖﯿﮐ يﺎﻫ ﯽﺻﺎﺼﺘﺧا ) ﺖﮐﺮﺷ سرﺎﭘ نﻮﻣزآ ( هزاﺪﻧا يﺮﯿﮔ ﺪﺷ . ﺞﯾﺎﺘﻧ ﺶﯾﺎﻣزآ ﺎﺑ هدﺎﻔﺘﺳا زا مﺮﻧ راﺰﻓا يرﺎﻣآ SPSS درﻮﻣ ﻪﯾﺰﺠﺗ و ﻞﯿﻠﺤﺗ يرﺎﻣآ راﺮﻗ ﺪﻨﺘﻓﺮﮔ هوﺮﮔ يﺪﻨﺑ ﻦﯿﮕﻧﺎﯿﻣ ﺎﻫ ﺎﺑ هدﺎﻔﺘﺳا زا نﻮﻣزآ ﺪﻨﭼ ﻪﻨﻣاد يا ﻦﮑﻧاد مﺎﺠﻧا ﺪﺷ و ياﺮﺑ ﻢﺳر رادﻮﻤﻧ زا مﺮﻧ راﺰﻓا Excel هدﺎﻔﺘﺳا ﺪﺷ . ﺶﻫوﮋﭘ يﺎﻫ ﻪﺘﻓﺎﯾ ﺳرﺮﺑ ﯽ ﺎﺘﻧ ﯾ ﺞ ﻞﺻﺎﺣ زا ﺰﯿﻟﺎﻧآ راو ﯾ ﺲﻧﺎ هداد ﺎﻫ نﺎﺸﻧ داد ﻪﮐ رد ﺎﻘﻣ ﯾ ﻪﺴ ﺎﺑ هوﺮﮔ ،لﺮﺘﻨﮐ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ﺐﺒﺳ اﺰﻓا ﯾ ﺶ يﺎﻫ ﺖﻈﻠﻏ ﯽﻣﺮﺳ روا ه) P<0.01 (، روا ﯾ ﮏ ﺳا ﯿ ،ﺪ BUN و ﺗاﺮﮐ ﯿﻨ ﯿ ﻦ ) P<0.001 ( دﺮﮔ ﯾﺪ .) يﺎﻫرادﻮﻤﻧ هرﺎﻤﺷ 1 ﺎﺗ 4( فﺮﺼﻣ مأﻮﺗ هرﺎﺼﻋ ﻫ ﯿ ﻠﮑﻟاورﺪ ﯽ ﮔ ﯿ هﺎ ﺮﺘﺷرﺎﺧ و ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ رد ﺎﻘﻣ ﯾ ﻪﺴ ﺎﺑ وﺮﮔ ه لﺮﺘﻨﮐ ﺐﺒﺳ ﺶﻫﺎﮐ راﺪﻘﻣ هروا و ﺗاﺮﮐ ﯿﻨ ﯿ ﻦ ﻣﺮﺳ ﯽ ) رد ﺢﻄﺳ لﺎﻤﺘﺣا ) P<0.05 ( و BUN و روا ﯾ ﮏ ﺳا ﯿﺪ ﺢﻄﺳرد لﺎﻤﺘﺣا ) P<0.001 ( دﺮﮔ ﯾﺪ . ﺎﻘﻣ ﯾ ﻪﺴ ﻣ ﯿ ﮕﻧﺎ ﯿ ﻦ هداد ﺎﻫ ي ﻞﺻﺎﺣ زا ﺮﺛا مأﻮﺗ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ و هرﺎﺼﻋ اﯾ ﻦ ﮔ ﯿ هﺎ نﺎﺸﻧ داد ﻪﮐ زود mg/kg 400 هرﺎﺼﻋ ﻫ ﯿ ﻠﮑﻟاورﺪ ﯽ ﮔ ﯿ هﺎ ﺮﺘﺷرﺎﺧ اﺰﻓا ﯾ ﺶ اﺪﻘﻣ ر هروا ﻣﺮﺳ ﯽ ﺷﺎﻧ ﯽ زا ﺴﮐﻮﺗوﺮﻔﻧ ﯿ ﺘﺴ ﯽ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ار رد ﺢﻄﺳ لﺎﻤﺘﺣا ) P<0.01 ( لﺎﻤﺘﺣا ﺢﻄﺳ رد ﻦﯿﻨﯿﺗاﺮﮐ ) P<0.05 ( ، و ﺪﯿﺳا ﮏﯾروا BUN ﺢﻄﺳ رد ) P<0.001 ( ﺪﻌﺗ ﯾ ﻞ ﻣ ﯽ ﺪﯾﺎﻤﻧ .) رادﻮﻤﻧ يﺎﻫ هرﺎﻤﺷ 1 ﺎﺗ 4(

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76 رادﻮﻤﻧ هرﺎﻤﺷ 1. تاﺮﯿﯿﻐﺗ ﺖﻈﻠﻏ ﻣﺮﺳ ﯽ هروا ﮑﻟاورﺪﯿﻫ هرﺎﺼﻋ ﯽﻨﻌﻣ رﻮﻃ ﻪﺑ ﺮﺘﺷرﺎﺧ هﺎﯿﮔ ﯽﻠ يراد ) P<0.05 ( يرﺎﻤﯿﺗ هوﺮﮔ رد ) G+Ext ( ﺶﻫﺎﮐ ﺐﺟﻮﻣ ، ﺮﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺮﺛا مﺮﺳ هروا ﺖﻈﻠﻏ ) هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﯾﺎﻬﻨﺗ ﻪﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ هﺪﻨﻨﮐ ﺖﻓﺎﯾرد ( ﺪﯾدﺮﮔ . =Ctrl هوﺮﮔ ﮐ لﺮﺘﻨ ، Ext = هوﺮﮔ هرﺎﺼﻋ ، G = ،ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ هوﺮﮔ G+Ext = ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺎﺑ مأﻮﺗ هرﺎﺼﻋ هوﺮﮔ رادﻮﻤﻧ هرﺎﻤﺷ 2 . ﻐﺗ ﯿﯿ تاﺮ ﺖﻈﻠﻏ ﻣﺮﺳ ﯽ ﺪﯿﺳا ﮏﯾروا هرﺎﺼﻋ ﻫ ﯿ ﻠﮑﻟاورﺪ ﯽ ﮔ ﯿ هﺎ ﺮﺘﺷرﺎﺧ ﻪﺑ رﻮﻃ ﻨﻌﻣ ﯽ راد ي ) P<0.001 ( هوﺮﮔ رد ) G+Ext ( ، ﺐﺟﻮﻣ ﺶﻫﺎﮐ ﺮﺛا ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ﺮﺑ ﺖﻈﻠﻏ ﺪﯿﺳا ﮏﯾروا مﺮﺳ ) هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﯾﺎﻬﻨﺗ ﻪﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ هﺪﻨﻨﮐ ﺖﻓﺎﯾرد ( دﺮﮔ ﯾﺪ . Ctrl = هوﺮﮔ ﻨﮐ ،لﺮﺘ Ext = هوﺮﮔ ،هرﺎﺼﻋ G = هوﺮﮔ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ،ﻦ G+Ext = هوﺮﮔ هرﺎﺼﻋ مأﻮﺗ ﺎﺑ ﻣﺎﺘﻨﺟ ﯾﺎ ﺴ ﯿ ﻦ

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77 رادﻮﻤﻧ هرﺎﻤﺷ 3 . ﻐﺗ ﯿﯿ تاﺮ ﺖﻈﻠﻏ ﻣﺮﺳ ﯽ ﻦﯿﻨﯿﺗاﺮﮐ هرﺎﺼﻋ ﻫ ﯿ ﻠﮑﻟاورﺪ ﯽ ﮔ ﯿ هﺎ ﺮﺘﺷرﺎﺧ ﻪﺑ رﻮﻃ ﻨﻌﻣ ﯽ راد ي ) P<0.05 ( رد هوﺮﮔ ) G+Ext ( ، ﺐﺟﻮﻣ ﺶﻫﺎﮐ ﺮﺛا ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ﺮﺑ ﺖﻈﻠﻏ ﯿﺗاﺮﮐ ﻦﯿﻨ مﺮﺳ ) هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﯾﺎﻬﻨﺗ ﻪﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ هﺪﻨﻨﮐ ﺖﻓﺎﯾرد ( دﺮﮔ ﯾﺪ . Ctrl = هوﺮﮔ ،لﺮﺘﻨﮐ Ext = هوﺮﮔ ،هرﺎﺼﻋ G = هوﺮﮔ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ،ﻦ G+Ext = هوﺮﮔ هرﺎﺼﻋ مأﻮﺗ ﺎﺑ ﻣﺎﺘﻨﺟ ﯾﺎ ﺴ ﯿ ﻦ رادﻮﻤﻧ هرﺎﻤﺷ 4 . ﻐﺗ ﯿﯿ تاﺮ ﺖﻈﻠﻏ ﻣﺮﺳ ﯽ BUN هرﺎﺼﻋ ﻫ ﯿ ﻠﮑﻟاورﺪ ﯽ ﮔ ﯿ هﺎ ﺮﺘﺷرﺎﺧ ﻪﺑ ﻮﻃ ر ﻨﻌﻣ ﯽ راد ي ) P<0.001 ( هوﺮﮔ رد ) G+Ext ( ، ﺐﺟﻮﻣ ﺶﻫﺎﮐ ﺮﺛا ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ﺮﺑ ﺖﻈﻠﻏ BUN مﺮﺳ ) هوﺮﮔ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﯽﯾﺎﻬﻨﺗ ﻪﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ هﺪﻨﻨﮐ ﺖﻓﺎﯾرد ( دﺮﮔ ﯾﺪ . Ctrl = هوﺮﮔ لﺮﺘﻨﮐ ، Ext = هوﺮﮔ ،هرﺎﺼﻋ G = هوﺮﮔ ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ،ﻦ G+Ext = هوﺮﮔ هرﺎﺼﻋ مأﻮﺗ ﺎﺑ ﻣﺎﺘﻨﺟ ﯾﺎ ﺴ ﯿ ﻦ ﺚﺤﺑ يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺎﺘﻧ ﯾ ﺞ اﯾ ﻦ ﻘﺤﺗ ﯿ ﻖ نﺎﺸﻧ ،داد هرﺎﺼﻋ ﻫ ﯿ ﻠﮑﻟاورﺪ ﯽ ﮔ ﯿ هﺎ ﺮﺘﺷرﺎﺧ ردﺎﻗ ﺖﺳا تاﺮﺛا ﺒﻧﺎﺟ ﯽ ﺘﻧآ ﯽ ﺗﻮﺑ ﯿ ﮏ ﻣآ ﯿ ﻠﮔﻮﻨ ﯿ زﻮﮑ ﯾﺪ ي ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ار ﺮﺑ ﻠﮐ ﯿﻪ ﺎﻫ ﺶﻫﺎﮐ ﺪﻫد . ﺎﻫﺮﮐرﺎﻣ ﯽﯾ ﻪﮐ نﺎﺸﻧ هﺪﻨﻫد دﺮﮑﻠﻤﻋ ﻠﮐ ﯿﻪ ﺎﻫ ﻣ ﯽ ،ﺪﻨﺷﺎﺑ ﺪﻨﺗرﺎﺒﻋ زا : ،هروا BUN ، روا ﯾ ﮏ ﺳا ﯿﺪ ﺗاﺮﮐو ﯿﻨ ﯿ ﻦ ﻪﮐ ﻌﻣ ﯿ رﺎ ي ﺮﺑ دروآﺮﺑ دﺮﮑﻠﻤﻋ

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78 ﻓﯿ ﺰﯾ ژﻮﻟﻮ ﯾ ﮏ هﺎﮕﺘﺳد راردا ي بﻮﺴﺤﻣ ﯽﻣ ﺪﻧﻮﺷ . هرﺎﺼﻋ ﮔﯿ ﻫﺎ ﯽ درﻮﻣ هدﺎﻔﺘﺳا رد اﯾ ﻦ ،ﻪﻌﻟﺎﻄﻣ زا ﺮﻃ ﯾ ﻖ ﺶﻫﺎﮐ ﺖﻈﻠﻏ ﺑﯿ ﺎﻫﺮﮐرﺎﻣﻮ ي ﻠﮐ ﯿﻮ ي دﻮﺟﻮﻣ رد ،نﻮﺧ ًﻻﺎﻤﺘﺣا ﺐﺟﻮﻣ ﺖﺸﮔﺮﺑ ﺖﻟﺎﺣ ﻓ ﯿﺰ ﯾ ژﻮﻟﻮ ﯾ ﮏ ﻠﮐ ﯿﻪ ﺲﭘ زا ﻮﺠﺗ ﯾﺰ وراد ي ﺎﻣﺎﺘﻨﺟ ﯾ ﺴ ﯿ ﻦ ) ﻞﻣﺎﻋ ﺳآ ﯿ ﺐ نﺎﺳر ﻪﺑ ﺖﻓﺎﺑ ﻠﮐ ﯿﻪ ( هﺪﺷ ﺖﺳا . ﺎﻫﺮﮐرﺎﻣ ي ﺺﺧﺎﺷ دﺮﮑﻠﻤﻋ ﺒﻃ ﯿﻌ ﯽ ﻠﮐ ﯿﻪ ﺎﻫ رد اﯾ ﻦ ﺳرﺮﺑ ﯽ درﻮﻣ زرا ﯾﺑﺎ ﯽ راﺮﻗ ﺖﻓﺮﮔ . ﺎﺘﻧ ﯾ ﺞ ﺑ ﻪ ﺖﺳد هﺪﻣآ زا اﯾ ﻦ ﻪﻌﻟﺎﻄﻣ ﺎﺑ ﺎﺘﻧ ﯾ ﺞ )

Coskun Silan. et al. (2007

، H. et al(2005) Parlakpinar ، Yung-Hu H. et al. (2014) ، Yi-Chien L. et al.(2013) ﺖﻘﺑﺎﻄﻣ دراد .) 8،11،12،14 ( ﯽﺘﻧآ ﮏﯿﺗﻮﯿﺑ يﺎﻫ ﯿﻣآ يﺪﯾزﻮﮑﯿﻠﮔﻮﻨ زا ﻪﻠﻤﺟ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﻪﺑ ﻞﯿﻟد ﯽﺸﺨﺑﺮﺛا ﯽﯾﻻﺎﺑ ﻪﮐ رد ﺮﺑاﺮﺑ ﺖﻧﻮﻔﻋ يﺎﻫ ﯽﺷﺎﻧ زا يﺮﺘﮐﺎﺑ يﺎﻫ مﺮﮔ ﯽﻔﻨﻣ ﺪﻧراد ، ًارﺮﮑﻣ درﻮﻣ هدﺎﻔﺘﺳا راﺮﻗ ﯽﻣ ﺪﻧﺮﯿﮔ ،) 3،31،32 .( عﻮﯿﺷ ﯽﺘﺴﯿﺴﮐﻮﺗﺮﻔﻧ ﯽﺷﺎﻧ زا فﺮﺼﻣ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ زا 3 ﺪﺻرد رد لﺎﺳ 1969 ﻪﺑ 20 ﺪﺻرد رد ﻪﻫد ﻪﺘﺷﺬﮔ هﺪﯿﺳر ﺖﺳا . ﻖﺒﻃ ﺞﯾﺎﺘﻧ ﺪﯾﺪﺟ دوﺪﺣ 30 ﺪﺻرد زا يداﺮﻓا ﻪﮐ ﺶﯿﺑ زا 7 زور ﺖﺤﺗ نﺎﻣرد ﺎﺑ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ راﺮﻗ ﯽﻣ ﺪﻧﺮﯿﮔ ﯽﺧﺮﺑ زا ﻢﺋﻼﻋ ﯽﺘﺴﯿﺴﮐﻮﺗوﺮﻔﻧ ار نﺎﺸﻧ ﻣ ﯽ ﺪﻨﻫد . ﻪﮐ ﺶﯾﺎﻣزآ درﻮﻣ تﺎﻧاﻮﯿﺣ ﺰﯿﻧ ﯽﺳرﺮﺑ ﻦﯾا رد تﺪﻣ 7 ﺖﻈﻠﻏ ،ﺪﻨﺘﻓﺮﮔ راﺮﻗ رﺎﻤﯿﺗ ﺖﺤﺗ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺎﺑ زور آ رد يﻮﯿﻠﮐ دﺮﮑﻠﻤﻋ يﺎﻫﺮﮐرﺎﻣ ن ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ ﺶﯾاﺰﻓا ﺎﻫ دﻮﻤﻧ اﺪﯿﭘ . فﺮﺼﻣ ﺎﻫوراد عﻮﻧ ﻦﯾا ﺎﺑ دﻮﺟو مﺎﻤﺗ ﺖﯾﺰﻣ ﯽﯾﺎﻫ ﻪﮐ ﺪﻧراد ، ﻪﺑ ﻞﯿﻟد ضراﻮﻋ ﯽﺒﻧﺎﺟ ﺎﺑ ﺖﯾدوﺪﺤﻣ وﺮﺑور ﺖﺳا ،) 8،32 (. ﺮﺑ سﺎﺳا يرﺎﯿﺴﺑ زا تﺎﻌﻟﺎﻄﻣ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺐﺒﺳ ﺶﯾاﺰﻓا ﺖﻈﻠﻏ ﺺﺧﺎﺷ يﺎﻫ ﯽﯾﺎﯿﻤﯿﺷﻮﯿﺑ دﺮﮑﻠﻤﻋ ﻪﯿﻠﮐ زا ﻪﻠﻤﺟ ﻦﯿﻨﯿﺗاﺮﮐ ﺎﻤﺳﻼﭘ ﯽﻣ ددﺮﮔ ،) 33 -11،31 (، ﺮﺑ ﻪﮐ ﺖﻘﺑﺎﻄﻣ ﻪﻌﻟﺎﻄﻣ ﻦﯾا زا ﻞﺻﺎﺣ ﺞﯾﺎﺘﻧ ﺎﺑ ﺎﻫ شراﺰﮔ سﺎﺳا دراد . لﺎﻤﺘﺣا دراد ﻦﯾا ﺶﯾاﺰﻓا ﻦﯿﻨﯿﺗاﺮﮐ ﺑ ﻪ ﻞﯿﻟد ﺐﯿﺳآ ﺖﻓﺎﺑ ﯽﻟوﺮﻣﻮﻠﮔ دﺎﺠﯾا هﺪﺷ ﻂﺳﻮﺗ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺪﺷﺎﺑ ،) 31 (، رد ﻪﯿﻠﮐ ﺎﻫ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺑ ﻪ ﯽﺘﺣار ﻪﯿﻔﺼﺗ هﺪﺷ و رد ﻪﻟﻮﻟ هﺪﯿﻤﺧ ﮏﯾدﺰﻧ بﺬﺟزﺎﺑ ﯽﻣ ددﺮﮔ . ﻪﺑ ﻤﻫ ﻦﯿ ﻞﯿﻟد زوﺮﮑﻧ ﯽﻟﻮﻠﺳ ﯽﺷﺎﻧ زا يوراد ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ًﺎﺗﺪﻤﻋ رد ﻪﻟﻮﻟ يﺎﻫ هﺪﯿﻤﺧ دﺎﺠﯾا ﯽﻣ دﻮﺷ ،) 33،34 (، شراﺰﮔ ﮏﯾ سﺎﺳا ﺮﺑ ﺶﯾاﺰﻓا ﻦﯿﻨﯿﺗاﺮﮐ ﺎﻤﺳﻼﭘ ﺖﺳا ﻦﮑﻤﻣ ﻪﺑ ﺮﻃﺎﺧ ﺐﯿﺳآ هدراو ﺮﺑ ﻪﻟﻮﻟ ﺎﻫ و ﺶﻫﺎﮐ ﻪﯿﻔﺼﺗ ﯽﻟوﺮﻣﻮﻠﮔ ﻪﺑ ﺖﻠﻋ داﺪﺴﻧا يرﺎﺠﻣ ﻂﺳﻮﺗ لﻮﻠﺳ يﺎﻫ هزوﺮﮑﻧ خر ﺪﺷﺎﺑ هداد ). 34 ( ﯽﺧﺮﺑ زا ﻦﯿﻘﻘﺤﻣ ﺶﯾاﺰﻓا ﺪﯿﻟﻮﺗ زا دازآ يﺎﻫ لﺎﮑﯾدار ﻪﻠﻤﺟ ﻪﻧﻮﮔ نﮋﯿﺴﮐا ﺮﯾﺬﭘ ﺶﻨﮐاو يﺎﻫ ، نﻮﯿﻧآ يﺎﻫ ،ﺪﯿﺴﮐاﺮﭘﻮﺳ نژورﺪﯿﻫﺪﯿﺴﮐاﺮﭘ و ﺶﯾاﺰﻓا نﻮﯿﺳاﺪﯿﺴﮐاﺮﭘ ﯽﺑﺮﭼ ار رد ءﺎﻘﻟا تاﺮﺛا ﯽﺒﻧﺎﺟ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺮﺛﺆﻣ ﯽﻣ ﺪﻨﻧاد ،) 17،18 (. شراﺰﮔ هﺪﯾدﺮﮔ ﻪﮐ ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺐﺒﺳ ﺮﯿﯿﻐﺗ ﺐﯿﮐﺮﺗ يﺪﯿﭙﯿﻟ يﺎﻫﺎﺸﻏ ﯽﻟﻮﻠﺳ رد ﻪﯿﻠﮐ ﯽﻣ دﻮﺷ ،) 28،33 (. لﺎﻤﺘﺣا دراد ﻦﯾا تاﺮﯿﯿﻐﺗ ﻂﺳﻮﺗ ﺖﯿﻟﺎﻌﻓ نﻮﯿﺳاﺪﯿﺴﮐاﺮﭘ يﺪﯿﭙﯿﻟ لﺎﮑﯾدار يﺎﻫ دازآ ﯽﺠﻧﺎﯿﻣ يﺮﮔ ددﺮﮔ ،) 35 (، رد ﻖﯿﻘﺤﺗ ﺮﺿﺎﺣ ناﻮﺗ ﯽﻣ ناﺰﯿﻣ ،هروا ،ﻦﯿﻨﯿﺗاﺮﮐ BUN و ﺳا ﯿ رواﺪ ﯾ ﮏ ار ﺶﯾاﺰﻓا داد زا ﻞﺻﺎﺣ ﺞﯾﺎﺘﻧ ﺎﺑ ﻪﺑﺎﺸﻣ ﻪﮐ ، تﺎﻌﻟﺎﻄﻣ نرﺎﮑﻤﻫ و ﺮﻫزا ) 2005 ( ﺪﺷﺎﺑ ﯽﻣ ،) 30 ( . ﺞﯾﺎﺘﻧ و ﻖﯿﻘﺤﺗ ﻦﯾا زا ﻞﺻﺎﺣ يﺎﻫ هداد ،هﺪﺷ مﺎﺠﻧا تﺎﻌﻟﺎﻄﻣ ﺪﯾﺎﻤﻧ ﯽﻣ ﺖﯾﻮﻘﺗ ار ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ زا ﯽﺷﺎﻧ ﯽﺘﺴﯿﺴﮐﻮﺗوﺮﻔﻧ . ﻦﯿﻣﺎﺘﯾو يﺎﻫ E و C ، ود ﻦﯿﻣﺎﺘﯾو ﺎﺑ ﺖﯿﺻﺎﺧ ﯽﺘﻧآ ﯽﻧاﺪﯿﺴﮐا ،ﺪﻨﺷﺎﺑ ﯽﻣ ﻪﮐ ﯽﺘﺴﯿﺴﮐﻮﺗوﺮﻔﻧ ﯽﺷﺎﻧ زا ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ار ﺶﻫﺎﮐ د هدا ﺖﺳا ﺞﯾﺎﺘﻧ داد نﺎﺸﻧ ﺰﯿﻧ ﺎﻣ هرﺎﺼﻋ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ ﺖﺳا ردﺎﻗ ﺖﻈﻠﻏ ،هروا ﮏﯾرواﺪﯿﺳا ، و ﻦﯿﻨﯿﺗاﺮﮐ BUN ﻪﺘﻓﺎﯾ ﺶﯾاﺰﻓا ﯽﺷﺎﻧ زا ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ار فﺮﻃﺮﺑ ﺪﻨﮐ . زا ﻓﺮﻃ ﯽ هﺎﯿﮔ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ يوﺎﺣ تﺎﺒﯿﮐﺮﺗ يﺪﯿﺋﻮﻧوﻼﻓ ) ﻞﺜﻣ ﻦﯿﺘﺳﺮﺋﻮﮐ ( و تﺎﺒﯿﮐﺮﺗ يﺪﯾزﻮﮑﯿﻠﮔ ﺖﺳا ،) 35 (، و ﺎﺑ ﻪﺟﻮﺗ ﻪﺑ دﻮﺟو تﺎﺒﯿﮐﺮﺗ يﺪﯿﺋﻮﻧوﻼﻓ رد ﻦﯾا هﺎﯿﮔ ﯽﻣ ناﻮﺗ رﻮﺼﺗ دﻮﻤﻧ ﻪﮐ ﯽﺸﺨﺑ د ﯾ ﺮﮕ زا تاﺮﺛا ﯽﺘﻇﺎﻔﺣ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ زا ﻖﯾﺮﻃ ﺖﯾﻮﻘﺗ ﻢﺘﺴﯿﺳ ﯽﺘﻧآ ﯽﻧاﺪﯿﺴﮐا و رﺎﻬﻣ ﺪﯿﻟﻮﺗ دازآ يﺎﻫ لﺎﮑﯾدار لﺎﻤﻋا ددﺮﮔ . ﺑ ﻪ رﻮﻃ ﯽﻠﮐ ، ﺞﯾﺎﺘﻧ ﻞﺻﺎﺣ زا ﻦﯾا ﻖﯿﻘﺤﺗ نﺎﺸﻧ داد ﻪﮐ هرﺎﺼﻋ ﯽﻠﮑﻟاورﺪﯿﻫ هﺎﯿﮔ ﯽﺟﺎﻬﻟا مورورﻮﺋﺎﻣ ﻪﻧ ﺎﻬﻨﺗ ﻪﯿﻠﮐ ﺎﻫ ار رد ﺮﺑاﺮﺑ ﯽﺘﺴﯿﺴﮐﻮﺗوﺮﻔﻧ ﯽﺷﺎﻧ زا ﻦﯿﺴﯾﺎﻣﺎﺘﻨﺟ ﺖﻈﻓﺎﺤﻣ ﯽﻣ ﺪﻨﮐ ﻪﮑﻠﺑ رد ﺖﻟﺎﺣ ﯽﻌﯿﺒﻃ ) نﺎﺳر ﺐﯿﺳآ ﻞﻣاﻮﻋ ﺖﻟﺎﺧد نوﺪﺑ ( ﺰﯿﻧ رد ﺶﻫﺎﮐ راﺪﻘﻣ هروا ، ،ﮏﯾرواﺪﯿﺳا ﯿﺗاﺮﮐ ﻦﯿﻨ و BUN نﻮﺧ ﺰﯿﻧ ﺮﺛﺆﻣ ﺖﺳا .) يﺎﻫرادﻮﻤﻧ هرﺎﻤﺷ 1 ﺎﺗ 4 ( نﺎﻫﺎﯿﮔ يﺎﯾاﺰﻣ زا ﯽﯾوراد ﯽﻣﻮﺑ و و ﯽﻋﺎﻨﺻ يﺎﻫوراد ﺎﺑ ﻪﺴﯾﺎﻘﻣ مﺎﻘﻣ رد ﻪﻘﻄﻨﻣ ،ﯽﺗادراو ضراﻮﻋ ندﻮﺑ ﺰﯿﭼﺎﻧ و ﯽﺑﺎﯿﺘﺳد ﺖﻟﻮﻬﺳ ،ﺖﺣار ﻪﯿﻬﺗ نآ ﻪﺘﺳاﻮﺧﺎﻧ و ﯽﺒﻧﺎﺟ ﺎﻫ ﯽﻣ ار دﺮﻤﺷﺮﺑ ناﻮﺗ . ﻪﯿﻟوا ﺖﺧﺎﻨﺷ ﺎﺑ يﺎﻫﺮﺘﻣارﺎﭘ ﺶﻫﺎﮐ رد ﺮﺘﺷرﺎﺧ هﺎﯿﮔ ﺪﯿﻔﻣ ﺶﻘﻧ ﻪﻄﺑار رد هﺪﻨﻨﮐ يﺮﯿﮕﺸﯿﭘ تاﺮﺛا و نﻮﺧ رد دﻮﺟﻮﻣ يﻮﯿﻠﮐ ﯽﻤﺳ رد ﯽﻟﺎﻤﺘﺣا رد ﯽﻌﯿﺳو تﺎﻌﻟﺎﻄﻣ ،ﯽﺘﺴﯿﺴﮐﻮﺗوﺮﻔﻧ دراﻮﻣ ﺮﻫ ﺮﺛا و هﺎﯿﮔ رد دﻮﺟﻮﻣ تﺎﺒﯿﮐﺮﺗ ﻖﯿﻗد ﯽﯾﺎﺳﺎﻨﺷ صﻮﺼﺧ ﺑ تﺎﺒﯿﮐﺮﺗ ﻦﯾا زا ماﺪﮐ ﻪ ﺑ يروﺮﺿ ﻪﻧﺎﮔاﺪﺟ رﻮﻃ ﻪ ﯽﻣ ﺮﻈﻧ ﺪﺳر . ﯽﺳرﺮﺑ ﺎﺑ ﻞﻤﻋ ﻢﺴﯿﻧﺎﮑﻣ ﺖﺧﺎﻨﺷ و ﺮﺘﺸﯿﺑ يﺎﻫ ﺖﻓﺮﺸﯿﭘ ﺖﻬﺟ رد ﯽﻣﺎﮔ هﺪﻨﯾآ رد ناﻮﺘﺑ ﺪﯾﺎﺷ ﯽﻫﺎﯿﮔ تﺎﺒﯿﮐﺮﺗ وراد ﻪﻨﯿﻣز رد لﻮﺤﺗ و دﻮﺑ ﺪﻫﺎﺷ ار ﯽﻫﺎﯿﮔ يﺎﻫ .

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Evaluating the Protective Effect of Hydroalcohlic Extract

of Arial Parts of Alhagi Maurorum on Gentamicin

induced-acute Nephrotoxicity in Rat

YaghoubianF1, Cheraghi J2*, Mahmudi M3

(Recived: May 19, 2013 Accepted: October 14, 2013) Abstract

Introduction: Gentamycin is an aminogl-ycoside antibiotic used to treat infections of various Gram-negative organisms. Despite the brilliant effect of gentamicin in the tre-atment of kidney problems, its side effects accopained with the administration of the antibiotics have limited its use.Antioxidant compounds found in medicinal plants are good candidate for protecting against the damaging of gentamicin. In the present study for the first time, the protective effect of hydroalcholic extract of aerial parts of Alhajy mayrorum against gentamicin-indu-ced nephrotoxicity in rat was evaluated.

Materials & Methods: 28 male wistar rats (weight range of 300 ± 20 g) were rand-omly divided into 4 groups (each group containing 7 rats). Group 1: Control group (Ctrl), group 2: only received extract (Ext), group 3: Gentamicin group (G), and group 4: received gentamicin together with extract (G+Ext). All rats received the desired co-mpounds for 8 days. In the last day blood

samples were taken and serum concent-rations of urea, uric acid, creatinine and BUN were measured.

Findings: Gentamicin caused a significant increase in serum urea (P<0.05), uric acid (P<0.001), creatinine (P<0.05) and BUN (P<0.001) levels of the rats under inv-estigation. Coadministration of gentamicin plus Alhajy mayrorum extract adjusted in-creased levels of the above biomarkers to normal values.

Discussion & Conclusion: Findings of this study showed that Alhajy maurorum extract can effectively prevents side effects of the gentamicin on the kidneys. Consequently, commercial extract of Alhajy maurorum may be used to prevent unwanted effects of gentamicin on kidneys.

Keywords: Alhagi maurorum, gentamicin, nephrotoxicity

1.Dept of Physiology, Islamic Azad University of Hamedan, Hamedan, Iran 2.Faculty of Para-Veterinary Medicine, University of Ilam, Ilam, Iran 3.Faculty of Science, Islamic Azad University of Hamedan, Hamedan, Iran * (Corresponding author)

References

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