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The role of heterogeneity in asthma: a structure-to-function perspective

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Figure

Fig. 1 Schematic of the Horsfield lung model. Individual airways are modeled with a lumped six element model with an alveolar tissue element tissue damping term (G) coupled to elastance (H) and an inertial tissue component  (Ialveolus (Cg) (reproduced with
Fig. 2 Modeled lung resistance (a) and lung elastance (b) derived from an airway tree model
Fig. 4 Hyperpolarized helium-3 MRI axial slice of a mild asthmatic (left panel), a moderate asthmatic (middle panel), and a severe asthmatic (right panel)
Fig. 5 Relationship between baseline CV and AHR. Here, AHR was (reproduced with permission from [measured by the concentration of methacholine that elicits a 20% decrease in the subject’s  FEV1 compared to baseline  (PC20) dose
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