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Loss of IL 10 signaling in macrophages limits bacterial killing driven by prostaglandin E2

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Figure

Figure 1.IL-10RBshown in black.selected known LPS-responsive costimulatorymolecules (CD40 and CD80) and chemokinegenes (CXCL2 and CXCL3) were compared be-tween WT (expression of CD14, CD16, and CD206 were as-sessed by flow cytometry
Figure 2.IL-10RBnormalized read counts of each of the exons of the IL-10RB gene in WT (−/− Mφs are unresponsive to IL-10
Figure 3.Loss of IL-10 signaling impairsTyphimurium killing in Msurvival measured by gentamicin protection as-say and reported as CFU/ml in kolf_2 and IL-10RB S.φs
Figure 4.IL-10 selectively inhibits the LPS-mediated transcriptional response in Mφs. (A) PC analysis (PCA) was performed on all expressed genes incontrol Mφs (n = 4) and IL-10RB−/− Mφs (n = 3) stimulated with either 20 ng/ml rhIL-10 (overnight) or 2 ng/ml
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