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Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts

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Figure

Table 1 Potential NAI resistance mutations in HPAI H7N9 virusfrom human cases
Fig. 1 Replication kinetics of recombinant viruses in MDCK cells. Cells were inoculated with the recombinant viruses at 37 °C, and culture supernatantsbrown square (were harvested at 0, 18, 24, 48, 72 and 96 h post-inoculation
Fig. 2 Crystal structure display of the four neuraminidase drug resistancesites of human infection with highly pathogenic avian influenza H7N9virus

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