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Can diclofenac ester prodrug promote direct penetration across the skin?

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Figure

Table 1. A summary of the in vitro fluxes across human epidermis.
Figure 2. Cumulative amount of diclofenac or its ester prodrugs penetrated across the human epidermis from the in vitro flux study
Figure 3. Cumulative amount of diclofenac or its ester prodrugs penetrated across the hairless rat skin from the in vitro flux study
Figure 4. The diclofenac plasma concentrations over the time from I.V. injection of 100 µg of diclofenac sodium into hairless rats
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