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Ribosome profiling reveals resemblance between long non coding RNAs and 5′ leaders of coding RNAs

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Figure

Fig. 1. Overview of lncRNA classificationpipeline. (A,B) High-throughput sequencing data(ribosome profiling and RNA-seq) from eight earlydevelopmental stages (A) is used to train a classifierwith RefSeq coding sequences (CDSs), 5� leadersand 3� trailers (B
Fig. 2. Ribosome profiles outline translated ORFs ofcoding genes. (A) Representative examples of ribosome-protected fragment (RPF) densities associated with protein-coding genes
Fig. 3. TOC distinguishes ORFs in 5�displayed in the gray box (TE, translational efficiency; IO, inside versus outside; FL, fragment length; DS, disengagement score)
Fig. 4. TOC refines classification of lncRNAs. (profiling read densities associated with three putative lncRNAs (Ulitsky et al., 2011), which had conflicting annotations in published zebrafish lncRNAsets (Pauli et al., 2012; Ulitsky et al., 2011)

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