• No results found

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

N/A
N/A
Protected

Academic year: 2020

Share "Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape"

Copied!
18
0
0

Loading.... (view fulltext now)

Full text

Loading

Figure

Figure 1. Surface expression of HER2 and IL13Rαgrafts.analyzed by flow cytometry. Shown are representative dot plots of 3 experiments
Figure 2. The HER2/IL13Rα2 tandem CAR (TanCAR) structure, its encoding transgene, and in silico interrogation of its docking properties
Table 1. Docking energies for individual FRP5-scFv and IL-13 mutein domains to HER2 and IL13Rα2, respectively, TanCAR to HER2 and IL13Rα2, and collective docking
Figure 3. Activity of GBM patients’ TanCAR T cells against autologous GBM and U373. (GBM cells compared with the unispecific CAR T cells, a pooled product of aliquots thereof (CARpool), T cells coexpressing both HER2 and IL13R(biCAR), and NT T cells, all g
+6

References

Related documents

If post-secondary institutions regard increasing classroom participation as a priority among its many initiatives, then one should expect the universities such as Soochow

MANOVA was performed to identify if there is a significant difference between students’ satisfaction domains among faculties in UiTM Negeri Sembilan towards the implementation

Two important consequences of our algorithm are as follows: (a) a set-based symbolic algorithm for parity games that requires quasi-polynomially many symbolic operations and O ( n

By investigating TDP-43 expression patterns after stroke in young and 12-month-old mice, we showed (i) a marked increase and accumulation of TDP-43 in cytoplasmic compartment in

As shown in Figure 1C, when the brain activation observed between the angry face and fixation conditions of both groups were compared, the patient group exhibited signifi-

Keywords: hexakis(dimethylsulphoxide)manganese(II) tetraoxochlorate(VII); hexakis(dimethylsulphoxide)zinc tetraoxochlorate(VII); phase transitions; melting points; transmitted

In this section we prove the classification theorem, in a more general case; we prove that there are 999 non- isomorphic, connected Dynkin diagrams associated with

Cancer Centre, between October 2014 and April 2018. All scans were performed as part of routine clinical work-up. From this cohort, 34 patients were included in this study according