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Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

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Figure

Figure 1. fication, ×40). (IRAK1 and IRAK4 expression levels and activation status in T-ALL
Figure 2. IRAK1/4 signaling inhibition impedes T-ALL proliferation. (A) IRAK4/1 inhibitor effects on the proliferation of various malignant T cell lines
Figure 3. TLR1-TLR2 engagement can augment T-ALL proliferation. ((2.5 A) CCRF-CEM cells were treated with Pam3CysK4 μg/ml) or control (PBS) in the presence or absence of either 5 mg/ml neutralizing anti-TLR2 antibody or isotype
Figure 4. In vivo intervention with IRAK1/4 inhibitor reduces T-ALL numbers and delays T-ALL pro-gression.T-ALL cells from 3 different patients
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