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Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

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Academic year: 2020

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Figure

Fig. 1.Comparison of the solution and crystal structures of MAL2Y92) shown as innot included in the crystal structure model; they are shown here for illustration purposes by dotted lines
Fig. 2.MAL is glutathionylated on cysteine 91. (A) Sequence alignment high-lighting MAL cysteine conservation across species
Fig. 4.C91A and H92P MAL mutants fail to reconstitute TLR4 signaling in MAL-deficient iBMDMs
Fig. 5.MAL mutants C91A and H92P cannot interact with MyD88. (plasmid DNA was kept constant by addition of relevant EV control
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