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Mapping of Apoptin-interaction with BCR-ABL1, and development of apoptin-based targeted therapy

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Figure

Figure 1: Apoptin kills both BCR-ABL1 positive and negative cells. (a) Elevated level of cleaved PARP-1 in 32Dp210 cells treated with apoptin
Figure 2: Apoptin interacts with the SH3-domain of Abl – confirmation of apoptin’s interaction with BCR-ABL1
Figure 3: Mapping and modeling of apoptin motif responsible for its interaction with BCR-ABL1
Figure 4: Apoptin-derived proline-rich motif preferentially kills BCR-ABL1-positive cells
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