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RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics

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Academic year: 2020

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Figure

Figure 1: RSK isoforms are required for GBM migration and invasion. A. Migration of U-373 cells was determined in the presence of RSK inhibitors (FMK and BID1870) or control DMSO
Figure 2: Individual RSK isoforms regulate GBM cell invasion in 3D. A. Stable U-373 MG cell lines with knocked down RSK1, -2, -3, or -4 isoform expression (shRSK1-4) or cells carrying a scrambled control vector (scr) were generated using two independent sh
Figure 4: RSK2 activity reduces cell adhesion to fibronectin and invasion into brain slices
Figure 5: Patient-derived GBM cells require RSK2 for invasion and migration. A. RSK1-4 are expressed in patient cells and are phosphorylated at S386 and T573 indicating likely activation
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