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[6] Gingerol Induces Cell Cycle Arrest and Cell Death of Mutant p53 expressing Pancreatic Cancer Cells

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Figure

Fig. 1. Effect of [6]-gingerol on survival of BxPC-3 and HPAC cells. [6]-Gingerol inhibited growth of both BxPC-3 andwas determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay as described in Materialsand methods
Fig. 4. Effects of [6]-gingerol on the expression of p21changed by [6]-Gingerol in BxPC-3 and HPAC cells
Fig. 5. Differential mode of death induced by [6]-Gingerol in pancreatic cancer cells expressing wt versus mutant p53.Cells were treated with 400 M of [6]-gingerol for 24, 28 and 72 hrs
Fig. 6. Western bolt analysis for MPAK and PI3K/AKTpathways in [6]-gingerol-treated pancreatic cancer cells.The BxPC-3 (A) and HPAC (B) were incubated with 400μM of gingerol for indicated times

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