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Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial

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Academic year: 2020

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Figure

Figure 1: Metagene building and assessment procedure.
Figure 2: Schematic description of metagene building and assessment. A.C.TCGA repository, generation of groups of patients expressing low (red), intermediate (blue) and high (green) protein levels
Figure 3: Ability of the model to identify groups of functionally related genes in the different sets
Figure 4: Interaction between RPPA-based metagenes and trastuzumab efficacy. A.indicate Multivariate Cox regression hazard ratios (HRs) and 95% confidence intervals (CIs) for trastuzumab benefit for distant disease-free survival (DDFS) according to the met
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