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In smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor

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Academic year: 2020

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Figure

Fig. 1 Pulmonary endothelial function, represented as cumulative Ach dose response curves in pulmonary artery rings from smokers (n = 34) and never-smokers (n = 8)
Fig. 2 Effect of SHH modulation on pulmonary artery ring relaxation. Treatment with the downstream SHH inhibitor GANT61 altered vasodilation (n = 27; p < 0.001) (a), whereas SHH upstream inhibition by cyclopamine (n = 27) had no effect (b)
Fig. 5 VEGF gene and protein expression levels in pulmonary artery rings, and the effect of tobacco smoking on VEGF gene expression.

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