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Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma

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Figure

Fig. 1 Expression level of PAR1 when activated by thrombin is correlated with endothelial-like transition in HCC cells.PAR1, endothelial, and EMT markers in different HCC cell lines and HUVEC
Fig. 2culture. PAR1 overexpression in PLC-PRF-5 cells can increase VM tube formation, and PAR1 knockdown can decrease VM tube formation inHepG2/M cells with and without thrombin stimulation
Fig. 3 (See legend on next page.)
Fig. 4 PAR1 internalization can promote Twist1 nuclear translocation.binding, as shown in the confocal microscopy images
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