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Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria

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Figure

Fig. 1 Mitofusin 2 knockdown rescues oscillatory Ca 2+ signals in cells with de-energised mitochondria
Fig. 2 Oscillations in matrix Ca 2+ by mitochondrial Na + –Ca 2+ exchange. In panels a –f, mitofusin 2 was knocked down and cells were pre-treated acutely with FCCP and oligomycin prior to LTC4 challenge
Fig. 3 Forward and reverse mode Na + –Ca 2+ exchanger. a After knockdown of MCU and MFN2, matrix Ca 2+ oscillations are induced by LTC4 in FCCP- FCCP-treated cells following a small rise in matrix Ca 2+ by 2 nM ionomycin
Fig. 4 Functional Na + –Ca 2+ exchange supports gene expression in cells with de-energised mitochondria
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