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Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors

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Figure

Figure 1. SoxB1 factors acts as transcriptional repressors to inhibit the expression of fgf3complete loss of expression of bothof wild-type Sox3 to inhibitstage and analysed at 4.5 hpf (fgf8approximately 100determined)
Figure 2. Sox3 can directly bind to a region upstream of fgf3sox3precipitate Sox3 and bound DNA
Figure 3. Induction of ectopic chdexpression ofinhibited by injection at 1–2 cell stage of a combination of morpholinos targeting both and gsc expression by dnSox3 requires Fgf signalling
Figure 4. Sox3 represses expression of chdcontrols organizer formation. Sox3 plays a central role in this model to repress Fgf signalling in addition to independently repressing other genesneeded for organizer formation
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