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Forecasting clinical dose response from pre clinical studies in tuberculosis research translational predictions with rifampicin

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Figure

Figure 1Compartmental sketch of the translational Multistate Tuberculosis Pharmacometric (MTP) model; left: pharmacokinetic models of each targetsystem; right: pharmacodynamic MTP model; abbreviations are explained in the article text and in Table 1.
Table 1 Parameters of the translational Multistate Tuberculosis Pharmacometric (MTP) model used for the translational predica-tions into the target systems
Table 1 Continued
Figure 2Prediction of hollow-fiber system experiments with rifampicin againstsum of F(OD) dosing, 2,100 mg twice daily; 4,200 mg once weekly; unbound rifampicin (RIF) pharmacokinetics (upper panels) and pharmacodynamic effect overtime (lower panels); circle
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