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A Chemical-Genetic Screen for Identifying Substrates of the Er Kinase Perk

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Figure

Figure 1.1 Signaling through the three branches of the Unfolded Protein Response. The ER stress kinase (PERK) span the ER membrane
Figure 1.2 Oncogenic functions of PERK. Restricted nutrient and oxygen conditions in the tumor microenvironment triggers UPR signaling in cancer cells
Figure 1.4 Analog-sensitive kinases can be used for pathway mapping. The analog-sensitive kinase substrates with thiophosphate
Figure 2.1 The gatekeeper residue for PERK is methionine 886. (A) Sequence alignment of the PERK
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