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Identification of tissue of origin in carcinoma of unknown primary with a microarray-based gene expression test

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Figure

Figure 1 Tissue of Origin Test workflow and results. RNA fromfrozen tissue is extracted, amplified, and biotin-labeled beforehybridization to a Pathchip™ microarray
Table 1 Patient characteristics
Table 2 Immunohistochemical and Tissue of Origin Test results
Figure 2 Distribution of tumor types in 21 CUPs. The Tissue of Origin Test called the majority of specimens definitively positive for a singletumor type; in the indeterminate calls, the TOO Test ruled out an average of nine tissue types per specimen.

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