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The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes

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Figure

Figure 1. Intradermal (i.d.) injection of MGO induces itch behaviors in mice. (A-B) Time course (A) and total number (B) of scratching bouts within 30 min induced control
Figure 3. Direct activation of TRPA1 channel is required for MGO-induced itch behaviors in mice
Figure 4. Mechanical itch is enhanced in STZ-induced diabetic mice. (A) Increased level of blood glucose (mmol/L) was confirmed in STZ-induced diabetic mice (in diabetic mice compared with control mice (displayed early enhanced mechanical allodynia behavio
Figure 8H). Thus, these data suggested that oxidative
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