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Japanese experience with milnacipran, the first serotonin and norepinephrine reuptake inhibitor in Japan

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Table 1 Comparison of principal adverse events reported in European and Japanese comparative studies of milnacipran vs imipramine and milnacipran vs mianserin
Table 2 Patients responding to milnacipran according to gender and frequency of episode
Figure 1 Response to milnacipran in patients stratifi ed by severity. Severity was defi ned by baseline MADRS; Severe = MADRS ≥ 31; moderate = MADRS 25–30; mild = MADRS 21–24; Response = reduction ≥50% of the baseline MADRS; Drawn from data from Sugawara et al (2006).
Figure 2 Response to milnacipran at different doses. 66 patients were randomized and titrated to a daily dose of milnacipran of either 75 mg or 150 mg over 2–3 weeks; This dose was then maintained stable for 8 weeks; 25 and 26 patients, respectively, completed the study in the 75 mg/d and 150 mg/d groups; Response = reduction ≥50% in HAMD17 from baseline; Remission = HAMD17 <7; Drawn from data from Kanemoto et al (2004).
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