Spot Diagnosis
Rheumatology Weekend
Mechanic Hand
• Hyperkeratosis and fissure of radial side of
2nd to 4th fingers and ulnar side of thumb
• Associate with antisynthetase syndrome
• Antibody associated: Anti aminoacyl tRNA
synthetase
Dermatomyositis
• Pathogenesis: Immune complex to vessel
• Ischemia due to vasculitis
• Pathology: perivascular and perifascicular
infiltration (CD4); perifascicular fiber
atrophy; degeneration and regeneration of muscle
Calcinosis Cutis
• Abnormal calcification of subcutaneous
tissue
• DDx: tophi, xanthoma, Heberden and
Lupus Panniculitis
• Panniculitis in LE
• Mostly found at face and limb girdles
• Post inflammation cause atrophy
Anti dsDNA
• Crithidia leuciliae
• Crithidia test is gold standard of anti
dsDNA test
• ELISA test: titer relate to disease activity in
Morphea
• Localized scleroderma
• Morphea type: patchy and ivory-colored
Secondary RP
• Clue of secondary RP
Age of onset older than 30 Asymmetrical
Abnormal nailfold capillary Abnormal serology
Abnormal CBC or ESR/CRP
Severe pain and/or develop digital ulcer, digital pitting, gangrene
Periungual Infarction
• Small to medium vasculopathy or
vasculitis
SSc-Pattern Nailfold Cap.
• Early: dilatation of capillary turn to giant
capillary, well-preserved distribution • Active: more dilatation and
microhemorrhage, mild disorganization • Late: almost absence dilatation and
hemorrhage, ramified neovascularization and intense disorganization
VEDOSS
• Very Early Diagnosis of SSc
• Major criteria: SSc pattern nailfold cap.;
Serology; RP
• Minor criteria: calcinosis cutis; esophageal
sphincter dysfunction; puffy fingers; digital ulcers; telangiectasia; ground-glass at
chest HRCT
• Diagnosis: 3 majors or 2 majors and 1
Discoid LE
• Chronic cutaneous LE
• Involve skin appendage cause atrophic
scar
• Typical: erythema or hypertrophic patch,
papule, plaque with follicular plugging and some atrophic center and telangiectasia
Cytoid Bodies
• Retinal vasculitis
• Cause exudate and hemorrhage of fundus
Sapporo
• Sapporo Snow Festival
• APS meeting Sapporo criteria 1999
GAVE
• Gastric Antral Vascular Ectasia
• Vasculopathy manifestation
What
Rheumatoid Nodule
• Granuloma like: central necrosis and
palisading histiocytes
• Associate with RF and ACPA
• Increase prevalence in A2756G
polymorphism of methionine synthase reductase gene
Tophi
• Granuloma like: central micro-crystal and
surrounding macrophage • Alcohol fixation
Eosinophilic Fasciitis
• Groove sign: furrows along fascia and
blood vessels
• DDx in scleroderma-liked: EF;
scleredema; nephrogenic systemic
Anti-Ro and Anti-La
• Neonatal lupus
• Associate antibodies: anti Ro/SSA and
anti La/SSB
• Manifestation: skin, hemato, liver, cardio
• Fluorinated steroid: dexamethasone and
Antiphospholipid
• Anticardiolipin: 40 units or 99th percentile
of IgG or IgM
• Anti β 2 glycoprotein I: 99th percentile of
IgG or IgM
• Anti phosphatidylserine
Erythema Ab Igne
• Differential diagnosis of livedo reticularis
• Long term exposure to heat
Scleroderma
• Vasculopathy: intema media thickening
• Fibrosis: loss of normal architecture of
dermal ridge, abnormal collagen bundle, loss of skin appendages
Sjogren Syndrome
• Inflammation of exocrine gland
• Autoimmune process: alpha frodin
• Anti Ro, anti La, RF
• Sicca symptom of eyes and mouth
• Mikculicz disease
Ultraviolet
• Trigger of SLE flare: UVB 290-310 nm
• Exposure of anti Ro and apoptosis of
Tinel Sign
• Carpal tunnel syndrome
• Associate: diabetes, hypothyroid, RA, SSc
crystal induced arthropathy, pregnancy, amyloidosis, mechanic use
Sjogren Syndrome
• Sialogram: cherry-blossom appearance
Rose Bengal
• Rose Bengal dye
• Keratoconjunctivitis sicca
• Schirmer’ test: less than 5 mm. within 5
min.
Parry-Romberg Syndrome
• Progressive hemifacial atrophy
• Skin and bone atrophy
En Coup de Sabre
Pannus
• Lymphoid follicle-like in synovial tissue
• Cytokine-driven: TNF alpha, IL-1, IL-2,
Saturnine Gout
• Lead poisoning and gout
• Roman God Saturn festival: heavy wine
Polyarteritis Nodosa
• PAN: medium-vessel vasculitis
• HBV-related and non HBV-related
• HBV-related treatment: antivirals, plasma
exchange and high-dose steroid
• Non HBV-related treatment: high-dose
Saddle Nose
• Rheum.: WG, relapsing polychondritis
• Hem.: NK/T cell lymphoma
Scleromalacia
• Episcleritis and scleritis are most common
• Thinning of sclera: scleromalacia
• Protrusion of vitreous body: scleromalacia
Anterior Uveitis
• Ciliary injection and hypopyon
• Extra-articular symptom of SpA
• AS: more unilateral
Poliosis
• Poliosis: absence or decrease melanin of
hair
• VKH: Vogt-Konayagi-Harada syndrome
• Autoimmune against melanin-containing
organ
• Neuro: meningitis, stroke-liked, CN palsy
• Eye: uveitis
Anti-TNF alpha
• Etanercept: fusion protein against soluble
TNF receptor
• Infliximab: chimerical mouse-human mab
• Adalimumab: fully-humanized mab
• Golimumab: fully-humanized mab