Cold-Chain Logistics Solution (Pharmaceuticals)

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Customer Pickup

Parcel Boxed with

Barcode Label

Cold-Chain Logistics Solution (Pharmaceuticals)

Workflow

The factory produces the Pharmaceuticals and places them in a Logistics Co. Cold-Chain Box. The factory logs into the Logistics Co. Pickup and Delivery Website, enters the required pickup and delivery information (product description, ship from address, pickup address, ship to address, selects special handling options, date and time of request) and selects the desired Service Level for pickup and delivery. The Logistics Co. Pickup and Delivery System assigns

and generates UPC barcode data for the shipping label. This information is saved in the Regional Logistics Co. Pickup and Delivery Database and is made available for download to the factory for its database. The Logistics Co. Pickup and Delivery System sends the Pickup and Delivery information to the appropriate contracted trucking company. The factory agent prints the Logistics Co. Shipping Label with the UPC barcode using the supplied information and affixes it to the Logistics Co. Cold-Chain Box. The selected Pickup Service Level is pickup before noon on the following day. The selected Delivery Service Level is Express Overnight delivery after 8:00 and before noon the following day.

1. Factory request Logistics Co. Pickup and Delivery Service a. Prints Logistics Co. Shipping Label with UPC Barcode 2. Cold-Chain Box with Logistics Co. Shipping Label

3. Data saved in Regional Logistics Co. Pickup and Delivery Database

a. May be saved in the Factory’s Tracking and Monitoring Database

b. Service Level Priorities Set 4. Data sent to Contracted Trucking Firm

a. Prioritized

b. Save in contracted trucking company’s database

The Logistics Co. Pickup and Delivery System using a Globe Tracker Service monitors the scheduled pickup according to its selected Service Level. If the vehicle does not record its pickup by 11:00, 1 hour before the Service Level Windows expires, an “alarm” message is sent to the Contracted Trucking Company’s dispatcher.

The Contracted Trucking Company’s vehicle arrives. There are a number of vehicle cold-chain and communications options that might be considered from that point forward.

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a. The Cold-Chain Vehicle is refrigerated / cooled

b. The Cold-Chain Vehicle is equipped with cargo area “Digital” Temperature Sensor that can be read by another device.

2. Non-Cold-Chain Vehicle a. No Cooling / No Sensor

i. Globe Tracker Time-in-Route monitoring

1. Some minimal assurance that Ice last from pickup to drop-off at Logistics Co. Depot

b. Cold-Chain “Insulated” Covered Tub

i. Insulated box can maintain temperatures between + 2ºc and 8ºC

ii. With Eutectic cold plates up to 12 hour en route with up to 5 drop off stops

iii. Integrated Wi-Fi RFID Tag with Digital Temperature Sensor

1. Cooled

a. Max-Life Ice under Sub-floor b. Eutectic Cold Plates

c. Electronic Cooling (Peltier Couple) – requires external power

3. Vehicle is equipped with Logistics Co. Tracking and Monitoring Communications “Terminal”

a. Barcode Reader

i. RFID Reader / In-process dispenser

b. Local Database, Globe Tracker / Logistics Co. Tracking and Monitoring Management Software and Globe Tracker Tracking and Monitoring Data Exchange Network Client Software.

c. Wi-Fi Interface

i. Communicates with Wi-Fi Sensors

1. Cold-Chain Tubs Temperature Sensor

a. Records Temperature Sensor when new box is added 1. Vehicle Cold-Chain cargo area Temperature Sensor

a. Records Temperature Sensor when new box is added d. Attached Temperature Probe

i. Used to take a temperature reading on the outside of the box to establish the box pickup condition

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i. Logistics Co. Tracking and Monitoring Communications “Terminal” records its GPS position when data is recorded

f. GSM / GPRS Radio

i. Logistics Co. Tracking and Monitoring Communications “Terminal” sends its “data” when new data is recorded or at fixed intervals like every 30 minutes

g. Logistics Co. Tracking and Monitoring Communications “Terminal” is recharged when in vehicle mounted cradle

4. “Vehicle” Tracking and Monitoring Communications Unit, Logistics Co. Tracking and Monitoring Local Area Unit and Logistics Co. Tracking and Monitoring Communications “Terminal

a. Logistics Co. Tracking and Monitoring Communications “Terminal” i. Barcode Reader

1. RFID Reader / In-process dispenser

b. Local Database, Globe Tracker / Logistics Co. Tracking and Monitoring Management Software and Globe Tracker Tracking and Monitoring Data Exchange Network Client Software.

c. Wi-Fi Interface

i. Communications with Vehicle Unit d. Attached Temperature Probe

i. Used to take a temperature reading on the outside of the box to establish the box pickup condition

e. Vehicle Unit Provides: i. GPS

ii. GSM / GPRS iii. Local Wi-Fi

f. Vehicle Unit reads Wi-Fi Temperature Sensors

i. Logistics Co. Tracking and Monitoring Communications Unit sends Vehicle GPS position, Terminal Local Database Data “Change” Data, and

Temperature Sensor Data at fixed programmed intervals, like every 30 minutes.

The Contracted Trucking Company’s Vehicle arrives and using the Logistics Co. Terminal the driver scans the Logistics Co. Shipping Label UPC barcode and takes an outside temperature reading on the box with attached temperature probe. Globe Tracker executes an Exchange Verification ensuring that the box being scanned is the correct box to be picked up and that the pickup time is consistent with the selected Service Level and the box outside temperature is within the specified Cold-Chain Range. Globe Tracker reports the Exchange Verification to the Factory for entry in its database, to the Contracted Trucking Company for entry into its database and to Regional Logistics Co. Pickup and Delivery Database.

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Parcel Boxed w ith Barcode Label

I. G l o b e T r a c k e r I. K e r r y A p p l i c a t i o n I. L o g i s t i c s C o . A p p l i c a t i o n Service Level Alarms

Time-in-Transit Alarms Exchange Verification Cold-Chain Data

Globe

Tracker

Logistics Applications Applications Customer Pickup

Upon a successful Exchange Verification the driver might affix an RFID Tag to the Logistics Co. Shipping Label and scan it and the UPC barcode again. This records the UPC Barcode and RFID Tag “association” in the Logistics Co. Tracking and Monitoring Communications “Terminal” Local Database, ultimately recorded in the Regional Logistics Co. Pickup and Delivery Database. Affixing the RFID Tag at the point of pickup reduces the task to adding an RFID Tag to a verified box one or a few at a time as compared to affixing tags to many

packages as they arrive at the depot for instance.

5. Contracted Truck arrives a. Scans UPC Barcode b. Temperature Probe

6. Globe Tracker Exchange Verification a. Correct Parcel

b. Service Level Compliance c. Cold-Chain Compliance

7. Records Time-Stamped Exchange Verification in Factory, Contracted Trucking and Regional Logistics Co. Pickup and Delivery Database

The Contracted Vehicle proceeds along its scheduled route picking up other parcels at other addresses. The Contracted Vehicle sends data to the Regional Logistics Co. Pickup and Delivery Database at fixed intervals or as new parcels are picked up depending upon the vehicle’s installed equipment. The Logistics Co. Pickup and Delivery System continues to track and analyze each parcel for Service Level Compliance and Routing. The selected Delivery Service Level for the box we are watching is Express Overnight delivery after 8:00 and before noon the following day. The Logistics Co. Pickup and Delivery System determines that the box must be on a flight leaving Beijing for Shanghai at 17:15 today. The Logistics Co. Pickup and Delivery System determines that box must arrive at the Beijing Depot no later than 15:00 to make it through the depot workflow and to the airport by truck in time for a 17:15 flight with some margin for error.

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Copyright © 2007 Globe Tracker, Inc. All rights reserved. Page 5 of 7 At 14:30 the Logistics Co. Pickup and Delivery System determines that Contracted Vehicle is still engaged in its pickup route and not moving toward the Logistics Co. Beijing Depot. The Logistics Co. Pickup and Delivery System sends an alarm message to the Logistics Co. Beijing Depot agent for action. The agent contacts the Contracted Trucking Company and they contact the driver of the vehicle carrying the box of interest. The driver changes course and heads directly for the Logistics Co. Beijing Depot.

8. Contracted Vehicle Sends Data at fixed intervals, at points-of-pickup or on-demand

a. Vehicle GPS position b. Local Database Changes c. Temperature Sensor Data

The box arrives at the Logistics Co. Beijing Depot. The receiving agent scans either the RFID Tags as the parcels enter the depot receiving portal or each UPC barcode on each box, one at a time. Globe Tracker’s EdgeMagic, from CYBRA, generates RFID Tags for those parcels that arrive without one and transparently updates the Logistics Co. Beijing Depot Database and the Regional Logistics Co. Pickup and Delivery Database with the UPC Barcode and RFID Tag association. The Logistics Co. Beijing Depot is setup with multiple “Station RFID Portals” that read RFID Tags and track parcels as they pass from station to station as well as handheld readers and “Geiger Counter” type readers to help depot personal manage the depot’s workflow. Globe Tracker is continuously collecting data from customers, contracted trucking companies and multiple Logistics Co. Depots

helping to manage field-workflow with “Private” Logistics Co. software applications running on Globe Tracker servers and depot-workflows running on Logistics Co. Depot servers and Logistics Co.’s Pickup and Delivery System.

The incoming boxes are sorted for Cold-Chain handling and routing. Each Cold-Chain box has its outside temperature probed for Cold-Chain

Compliance. Cold-Chain boxes requiring attention are routed to Cold-Chain Stations where they are scanned in, brought into temperature compliance and scanned out to continue through the depot workflow. Each time a box is scanned and temperature probed the scanned and probed data is saved in the Logistics Co. Beijing Depot Database and the Regional Logistics Co. Pickup and Delivery Database.

Cold-Chain parcels are placed in “route specific” Cold-Chain Insulated Tubs and are queued for shipping according to their Service Level requirements. The Cold-Chain Tub ID is scanned and the parcel barcodes and or RFID Tags are “associated” with its ID. The Cold-Chain Tub carrying the box of interest is moved quickly to the shipping area with other parcels and Tubs being routed to the Beijing airport for evening departures, some on even earlier flights than our box

Globe Tracker Logistics Applications Applications Applications Applications

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Tracker

Logistics Applications

and coordinated with parcels from another Beijing Depot being transported to the airport on the same Contracted Trucking Company Vehicle. The Regional Logistics Co. Pickup and Delivery System uses the Globe Tracker Tracking and Monitoring Data Exchange Network to coordinate communications and data between the two depots and Region Control Center.

The Contracted Trucking Company’s Vehicle arrives and using Logistics Co. “Terminal” the driver scans the separate parcels, either their Logistics Co. Shipping Label UPC Barcode or their RFID Tags. The driver scans the Col-Chain Tub Wi-Fi RFID Tag and its integrated Temperature Sensor. Globe Tracker executes an Exchange Verification ensuring that the

parcels and Cold-Chain Tub being scanned is the correct cargo to be picked up, that the pickup time is consistent with the selected Service Level and the Chain Tub temperature is within the specified Cold-Chain Range. Globe Tracker reports the Exchange Verification to the Logistics Co. Depot for entry in its database, to the Contracted Trucking Company for entry into its database and to the Regional Logistics Co. Pickup and Delivery Database.

Upon the successful Exchange Verification the driver departs for the airport. As the vehicle travels to the airport it reports its GPS and Cold-Chain Tub Temperature along the way either through the Logistics Co. Terminal or the vehicles tracking and

monitoring unit. Globe Tracker monitors and analyzes the data to ensure Service Level, Time-in-Transit and Cold-Chain

Range Compliance. The Contracted Trucking Company vehicle arrives at the airport and is met by a Logistics Co. agent

equipped with a Logistics Co. Terminal. An Exchange

Verification is executed at the airport and the cargo is loaded into the aircrafts cargo bay. The Cold-Chain Tubs “radio” is disabled for flight but continues to collect and save temperature data. The aircraft arrives in Shanghai and is met by another Logistics Co. agent and a Contracted Trucking Company’s vehicle. The cargo is scanned as it is unloaded from the aircraft and the Cold-Chain Tub radio is “enabled” and its data transferred to the Logistics Co. agents Terminal. The Logistics Co. agent executes and Exchange Verification with the Regional Logistics Co. Pickup and Delivery System to ensure that “all” the cargo arrived, nothing extra and all in Service Level, Time-in-Transit and Cold-Chain Compliance. The Contracted Trucking Company’s vehicle departs for the Logistics Co. Shanghai Depot.

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Budgetary Cost:

Passive RFID Tags – $0.10 to $0.35 USD

Battery Assisted RFID Tags - $1.00 to $2.00 USD

Wi-Fi RFID Tags w Temp Sensor (Tubs) - $35 to $50 USD RFID Logistics Portal Reader - $800 to $1500 USD

RFID Handheld Reader - $250 to $500 USD Barcode Scanner - $100 to $200 USD

Cold-Chain Insulated Tub (600 liter) - $350 to $600 USD Logistics Co. Terminal - $1000 to $2000 USD