AUDITORIUM ALFREDO KRAUS

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AUDITORIUM ALFREDO KRAUS

LAS PALMAS DE GRAN CANARIA

JUNE 27-29th 2014

groupgem.org

Activity accredited by the Catalan Council

for Continuing Medical Education 09/10879-MD 1,6 Credits

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Scientific Committee

Robert Ballotti. Mediterranean Research Center for Molecular Medicine. Nice. France

Boris Bastian. UCSF Cardiovascular Research Institute. San Francisco, U.S.A

Alfonso Berrocal. Hospital Universitario General de Valencia. Valencia, Spain

Corine Bertolotto. Institut National de la Santé et de la Recherche Médicale (INSERM). Nice, France

Miguel Ángel Cabrera. Hospital Universitario Nuestra Sra. de La Candelaria. Tenerife, Spain

Luis de la Cruz. Hospital Universitario Virgen de Macarena. Sevilla, Spain

Irwin Davidson. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC). Strasbourg, France

Enrique Espinosa. Hospital Universitario La Paz. Madrid, Spain

Colin Goding. Nuffield Department of Clinical Medicine. Oxford, UK

María González Cao. Instituto Oncológico Dr. Rosell. Barcelona, Spain

Salvador González. Memorial Sloan Kettering Cancer Center. New York, U.S.A.

Lionel Larue. Institute Curie. Paris, France

Josep Malvehy. Hospital Clínico de Barcelona. Barcelona, Spain

Iván Márquez. Hospital Universitario Gregorio Marañón. Madrid, Spain

Salvador Martín Algarra. Clínica Universidad de Navarra. Pamplona, Spain

Alain Mauviel. Institute Curie. Paris, France

Martin McMahon. UCSF Helen Diller Family Comprehensive Cancer Center. San Francisco, U.S.A.

Eduardo Nagore. Instituto Valenciano de Oncología (IVO). Valencia, Spain

Juana Oramas. Hospital Universitario de Canarias. Tenerife, Spain

Daniel Peeper. Netherlands Cancer Institute. Amsterdam, Netherlands

Héctor Peinado. Cornell University. New York, U.S.A.

Antoni Ribas. University of California. Los Angeles, U.S.A.

Luis Ríos. Hospital Universitario Ramón y Cajal. Madrid, Spain

Delvys Rodríguez. Hospital Universitario Insular de Gran Canaria. Las Palmas, Spain

José Luis Rodríguez Peralto. Hospital Universitario 12 de Octubre. Madrid, Spain

Ze'ev Ronai. Sanford-Burham Medical Research Institute. La Jolla, U.S.A

Yardena Samuels. Weizmann Institute of Science. Rehovot, Israel

Salvador Saura. Hospital Universitario Dr. Negrín. Las Palmas, Spain

María S. Soengas. Centro Nacional de Investigaciones Oncológicas (CNIO). Madrid, Spain

Ainara Soria. Hospital Universitario Ramón y Cajal. Madrid, Spain

Eirikur Steingrimsson. University of Iceland. Reykjavík, Iceland

Thomas Tüting. University of Bonn. Bonn, Germany

GEM

Enrique Espinosa Salvador Martín Algarra Delvys Rodríguez

WORKSHOP

Josep Malvehy Susana Puig Antoni Ribas María S. Soengas

Organizing Committee

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We are pleased to announce that the ‘V International Symposium of GEM’ and the

‘6th European Melanoma Workshop’ will take place in the Auditorium Alfredo Kraus of

Las Palmas de Gran Canaria, Spain, on the 27th, 28th & 29th of June 2014.

The objective of the SYMPOSIUM is to offer better treatments for the patients by sharing

new ideas, experiences and improving the prevention and investigation of new treatments

for this pathology.

VENUE

AUDITORIUM ALFREDO KRAUS

LAS PALMAS DE GRAN CANARIA

Av. Príncipe de Asturias, s/n

35010 Las Palmas de Gran Ganaria

Islas Canarias (Spain)

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Friday, June 27th

15:00h - 16:20h GEM SYMPOSIUM

Room Cámara

15:00h - 15:15h

Opening

Excma. Dña. Brígida Mendoza Bethencourt

Salvador Martín Algarra & Delvys Rodríguez

15:15h - 15:35h

Melanoma in Spain: Recent Progress

Chair: Delvys Rodríguez

Speaker: Luis de la Cruz

15:35h - 16:20h

Oral Communications

Chairs: Juana Oramas & Miguel Ángel Cabrera

16:20h - 16:25h

MelaNet: Presentation Academic Course 2014

Salvador Martín Algarra

16:25h - 16:45h COFFEE BREAK

Room Gran Canaria & Room Tenerife

16:45h - 17:45h GEM GENERAL ASSEMBLY

Room Cámara

18:00h - 19:15h GEM - EUROPEAN MELANOMA WORKSHOP

Room Cámara

18:00h - 18:15h

Introduction

Salvador Martín Algarra & María S. Soengas

18:15h - 19:15h

Melanoma Immunotherapy

Chair: Delvys Rodríguez

18:15 - 18:45h PD1/PDL1

Antoni Ribas

18:45 - 19:15h Combined Targeting of Immunological Checkpoints

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Saturday, June 28th

Room Cámara

09:00h - 10:00h ASCO 2014

Chair: Enrique Espinosa

09:00h - 09:30h ASCO 2014 - Tyrosine-Kinase Inhibitors

María González Cao

09:30h - 10:00h ASCO 2014 - Immunotherapy

Alfonso Berrocal

10:00h - 11:30h

Melanoma Initiation

Chair: Ze'ev Ronai

10:00h - 10:30h Risk Factors in Melanoma Development

Josep Malvehy

10:30h - 11:00h Early Events in Melanoma Dissemination

Boris Bastian

11:00h - 11:15h Phase II Study Evaluating Ipilimumab as a Single Agent in the First-line Treatment of Adult Patients with Metastatic Uveal Melanoma (MUM): The GEM-1 Trial

Josep Mª Piulats

11:15h - 11:30h Re-routing of the Lymphatic Vasculature During Melanoma Progression

Steven Proulx

11:30h - 12:00h COFFEE BREAK

Room Cámara

12:00h - 13:30h

New Melanoma Drivers and Drug Targets (I)

Chair: Josep Malvehy

12:00h - 12:30h Deciphering the Role of Melanoma – Secreted Exosomes in Metastasis

Héctor Peinado

12:30h - 13:00h Targeting the Lymphatic System

María S. Soengas

13:00h - 13:30h Mutational and Functional Analysis in Melanoma-Looking for New Therapeutic Targets

Yardena Samuels

13:30h - 15:00h LUNCH

Room Alegranza

POSTER VIEWING

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Saturday, June 28th

Room Cámara

15:00h - 16:15h

New Melanoma Drivers and Drug Targets (II)

Chairs: Martin McMahon & María S. Soengas

15:00h - 15:30h In Vivo RNAi Screening for Novel Therapeutic Melanoma

Daniel Peeper

15:30h - 16:00h PI3'-Kinase Isoform Selectivity in the Progression and Maintenance of BRAF Mutated Melanoma

Martin McMahon

16:00h - 16:15h In Vivo Identification of Novel Determinants of Melanoma Progression

Daniela Bossi

16:15h - 16:45h COFFEE BREAK

16:45h - 18:45h Concurrent Session I

Room Cámara

16:45h - 17:35h

Challenges in the Diagnosis of Melanocytic Lesions

Chairs: Salvador González & Luis Ríos

16:45h - 17:10h Dermoscopy, Confocal Microscopy and Other Imaging Techniques in the Early Diagnosis and Management of Melanoma

Josep Malvehy

17:10h - 17:35h Molecular Markers for Melanoma Diagnosis

José Luis Rodríguez Peralto

17:35h - 18:25h

Familiar Melanoma. Discovering New Driver

Somatic Mutations

Chairs: Salvador Saura & Ainara Soria

17:35h - 18:00h TERT - Promoter Mutation

Eduardo Nagore

18:00h - 18:25h The FAM-GEM Study

Iván Márquez

18:25h - 18:45h

Closure GEM Symposium

Salvador Martín Algarra

16:45h - 18:45h Concurent Session II

Room Atlántico

16:45h - 18:45h

Lessons from Model Systems

Chair: Corine Bertolotto

16:45h - 17:15h PDK1 and ATF2 - Lessons from Genetic Models

Ze'ev Ronai

17:15h - 17:45h Caveolin Plays a Critical Role in PTEN-induced in Melanomagenesis

Lionel Larue

17:45h - 18:15h UV Irradiation, TLR4-Dependent Neutrophilic Infammation and Melanoma Metastasis

Thomas Tüting

18:15h - 18:30h Unraveling the Anticancer Mechanism of the Autophagy Inhibitor Chloroquine In Vivo

Hannelore Maes

18:30h - 18:45h Proteomic Characterization of Exosomes Reflects Melanoma Aggressiveness

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Sunday, June 29th

Room Cámara

09:00h - 10:45h

Melanoma Biology

Chair: Robert Ballotti

09:00h - 09:25h Melanoma: Senescence and Stem Cell-Like Phenotypes

Corine Bertolotto

09:25h - 09:50h Subcellular Localization of MITF

Eirikur Steingrimsson

09:50h - 10:15h Using Single Cell Transcription Profiles to Investigate Melanoma Heterogeneity

Irwin Davidson

10:15h - 10:30h G12DNRAS and Kinase-dead BRAF Cooperate to Drive Naevogenesis and Melanomagenesis

Malin Padersen

10:30h - 10:45h ATF2 in BRAF Mutant Melanoma

Giuseppina Claps

10:45h - 11:15h COFFEE BREAK

11:15h - 12:20h

Plasticity and Heterogeneity

Chair: Alain Mauviel

11:15h - 11:40h The Role and Regulation of MITF in Melanoma Phenotype-Switching

Colin Goding

11:40h - 12:00h Melanoma Therapy; MAPK Pathway and Beyond

Robert Ballotti

12:00h - 12:20h Contribution of GLI2 to the Transcriptional Control of the Cadherin Switch in Melanoma Cells

Alain Mauviel

12:20h - 13:00h CLOSING REMARKS

María S. Soengas & Josep Malvehy

For registration and additional

information about accomodation

or abstracts, please visit:

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Activity accredited by the Catalan Council for Continuing Medical Education

09/10879-MD 1,6 Credits

Contributors

Golden Sponsor

Technical Secretariat

MARKETING FARMACÉUTICO & INVESTIGACIÓN CLÍNICA, S.L.

Secretari Coloma, 64-68, esc. B, entlo. 5ª 08024 Barcelona

[email protected]

Mobile Phone: (34) 628-386-965 Phone: (34) 934-344-412 Fax: (34) 932-531-168

Silver Sponsor

Bronze Sponsor

Symposium held under the auspice of the Spanish Society of Medical Oncology