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Optimization of a forced degradation study of atorvastatin employing an experimental design approach

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Figure

Fig. 1. Graphical presentation of the obtained results from preliminary degradation study
Fig. 2C: Thermal degradation Fig. 2D: oxidative degradation Pareto Chartt-Value of |Effect|Rank0.002.645.277.9110.55Bonferroni Limit 6.57968t-Value Limit 3.182451234567CABCB Pareto Chartt-Value of |Effect|Rank0.002.945.888.8311.77 Bonferroni Limit 11.7687t
Fig. 3. Pareto chart representing the relationship between each factor and their interaction for oxidative degradation  where red line is Bonferroni limitation line
Fig. 4a: Acid degradation; Fig. 4b: Alkali degradation; Fig. 4c: Thermal degradation; Fig
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