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Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

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Figure

Fig. 1 Galectin-1 is expressed in different BP-ALL subtypes.HRP-conjugated goat anti-mouse antibodies
Fig. 2 PTX008 inhibits binding of Galectin-1 to the surface of ALL cells. LAX56 cells (2 × 104) were plated without OP9 stroma and treated for 1 hwith DMSO or 10 μM PTX008
Fig. 3 Galectin-1-mediated adhesion to fibronectin is inhibited by PTX008. a-c Representative analysis of (a) US7, (b) LAX56 or (c) LAX57 cellsadhering to fibronectin (left panels) or poly-L-lysine coated plates (middle panels) in the presence of increasin
Fig. 4 Galectin-1 inhibition reduces ALL cell migration. US7 (towardstandard deviation (**,each
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