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Time-varying SMART design and data analysis methods for evaluating adaptive intervention effects

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Academic year: 2020

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Figure

Fig. 1 Example of time-varying two-stage SMART design with equal probability allocation: each participant is randomized twice
Fig. 2 Example of time-varying two-stage SMART design with unequal probability allocation: only non-responders are re-randomized in thesecond stage
Table 2 Simulation results for the design in Fig. 1: the estimated means, based on 500 replicates, are reported for the finaloutcomes of the eight adaptive interventions embedded in the design
Table 3 Simulation results for the design in Fig. 1: the estimated means, based on 500 replicates, are reported for coefficients inmodel (4) with interactions
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