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Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case

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Figure

Fig. 1 Coronal in vivo [F-18]-AV-1451 PET images of the PD subject. The color scale indicates SUVR range from 1 to 2
Fig. 2 (See legend on next page.)
Fig. 3 Coronal in vivo [F-18]-AV-1451 PET images (a, left), matching autopsy tissue blocks (a, right), representative images of SDD-AGE membranesstained with total tau and PHF-1 antibodies (b), and correlation analyses between in vivo SUVR retention values
Fig. 4 Basal ganglia tissue sections stained with PHF-1 antibody (left), [F-18]-AV-1451 autoradiography (middle) and blocking with 1 μm unlabeledAV-1451 (right) from 2 AD patients, 2 CTL and 2 non-AD tauopathy subjects
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