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Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

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Figure

Fig. 1 (See legend on next page.)
Fig. 2 Poly(I:C)c reduces tumor mass in PDAC concomitant with enhanced T cell activation and reduced suppressive capacity of MDSC
Fig. 3 Poly(I:C)c triggers transcriptional reprogramming of MDSC. Mice with orthotopic T110299 tumors were treated twice with poly(I:C)c prior tosacrifice as described before
Fig. 4 MDSC of treated mice do not acquire professional antigen presenting cell function.orthotopic ovalbumin expressing PDAC (T112099-OVA) were treated with poly(I:C)* a-b Schematic representation of differential geneexpression upon poly(I:C)c treatment a
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