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Evaluation of 111In-Labeled Cyclic RGD Peptides: Effects of Peptide and Linker Multiplicity on Their Tumor Uptake, Excretion Kinetics and Metabolic Stability

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Figure 1. Cyclic RGD peptide tetramer conjugates: DOTA-6G-RGD4, DOTA-6P-RGD4, DOTA-2P-RGD4 and DOTA-2P4G-RGD4
Figure 2. Competitive inhibition curves of 125I-c(RGDyK) bound to the U87MG human glioma cells by c(RGDyK), DOTA-P-RGD, DOTA-P-RGD2, DOTA-3P-RGD2, DOTA-2P-RGD4, DOTA-2P4G-RGD4, DOTA-6P-RGD4 and DOTA-6P-RGK4
Table 1. Radiochemical purity (RCP), HPLC retention time and log P values for 111In-labeled cyclic RGD peptides
Table 6. Selected biodistribution data of 111In(DOTA-6P-RGD4) in athymic nude mice (n = 5) bearing U87MG human glioma xenografts
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