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Durable and sustained immune tolerance to ERT in Pompe disease with entrenched immune responses

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Figure

Table 1. Patient demographics and GAA mutation data for the 3 patients with infantile Pompe disease.A
Figure 1. Dosing profile of recombinant human acid alpha-glucosidase (rhGAA) and immunomodulation, as well as rhGAA IgG antibody titers, left ventricu-urinary Glcleft ventricular mass index; ERT, enzyme replacement therapy; IVIG, i.v
Table 2. Key laboratory findings at enzyme replacement therapy start, bortezomib start, and at most recent follow-up at time of database lock for the 3 patients with infantile Pompe disease.A
Figure 2. Dosing profile of recombinant human acid alpha-glucosidase (rhGAA) and immunomodulation, as well as rhGAA IgG antibody titers and left ven-tricular mass index (g/m2) over time for Patient 2
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