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The Development and Application of Computational Methods for the Prediction of G Protein Coupled Receptor Structures

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Figure

Figure 1. The hydrophobic profiles for the multiple sequence alignment of the 5-HT2C based on aligning the entire sequence
Figure 2. The hydrophobic penalty, energy, and number of hydrogen bonds for
Figure 3.  The final predicted structure of apo-5-HT2C.  Indicated explicitly are the six amino acids expected to be involved in important interhelical or ligand binding interactions
Figure 4. The structures and experimental binding constants to 5-HT2C for serotonin, three strongly binding antagonists, and a set of psilocybin analogs (derivatives 3 to 16)
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