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Transcription factor mutations as a cause of familial myeloid neoplasms

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Figure

Table 1. Mutations in DNA repair genes implicated in cellular mechanisms of familial MDS/acute leukemia
Figure 1. Ensuring normal hematopoiesis by establishing and maintaining genetic network integrity
Figure 2. Pathogenic consequences of GATA-2 deficiency and excess. Physiological GATA-2 levels in HSPCs are conferred by the Gata2 +9.5 and –77 enhancers in the mouse, and these enhancers are conserved in humans (14)
Table 3. Hematopoietic transcription factors implicated in familial MDS/acute leukemia syndromes: germline presentations
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