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Development of a biotechnological toolkit for the synthesis of diverse cyclic peptides

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Figure

Figure 1.1: Clinically available cyclic peptide drugs Examples of structurallydiverse, clinically available cyclic peptide drugs.
Figure 1.2: Cyanobactins (a) Gene clusters from patellamide (pat), trunkamide(tru),aestuaramide(lyn),microcyclamide(mic),cyanothecamide(cya)andarthrospiramide (art) pathways.Gene clusters encode a N-terminal protease (A,orange), heterocyclase (D, purple),
Figure 1.3: Patellamides Patellamides A, B, C and D. Trademark structural featuresinclude d-stereocentres, and thiazole and oxazoline heterocycles[27,28]
Figure 1.4: Pgp in complex with cyclic peptides QZ59-RRR and QZ59-SSS(a) structure of cyclic-tris-(R)-valineselenazole (QZ59-RRR)
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