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Control of cyclic oligoadenylate synthesis in a type III CRISPR system

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Figure

Figure 1. The CRISPR locus and cOA signalling proteins in(grey), a Csm/III D system (dark blue) and Cmr/III B system (light blue)
Figure 2. S. solfataricusan active cyclase domain. They represent a range of linear and cyclic polyadenosines of varying sizes
Table 1. Oligonucleotides.
Figure 3. The Csx1 nuclease is activated by linear cOA analogues generated by MazF. (linear oligoadenylate species were incubated with Csx1 nuclease along with acyclic 3’-phosphate termini by MazF
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