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Gadd45b deficiency promotes premature senescence and skin aging

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Figure

Figure 1: Decreased proliferation and premature senescence of Gadd45b-/- MEFs. A. Gadd45b+/+ (WT - solid black) and Gadd45b-/- (KO - solid grey) MEFs were cultured at 21% oxygen continuously for 14 passages
Figure 2: Premature senescence associated with Gadd45b deficiency can be rescued, in part, by culture at low oxygen
Figure 3: Loss of Gadd45b results in an accumulation in G2/M. A. Gadd45b+/+ (WT) and Gadd45b-/- (KO) MEFs were cultured at 21% oxygen
Figure 4: Defective G2/M cell-cycle progression of Gadd45b-/- MEFs. A. The mitotic index was determined in Gadd45b+/+ (WT) and Gadd45b-/- (KO) MEFs cultured at 21% oxygen at passage 9
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