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Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors?

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Figure

Fig. 1 Microsatellite instability is central in colorectal cancer carcinogenesis in both hereditary nonpolyposis syndrome and sporadic colorectal cancerthrough germ-line mutations in MMR genes or by hMLH-1 DNA methylation in the CIMP-H, respectively

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