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TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer families

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Figure

Table 1 Current genetic testing criteria for LFS
Table 2 Patient criteria for genetic testing according to NCCN clinical practice guidelines in oncology v.1.2010 [21] forHBOC
Figure 1 TP53the p.R337H mutation detection. A) Melting curves for each specific genotype identified in exon 10 of the TP53 gene containing TP53 p.R337H mutation; B) Sequencing results of a heterozygous TP53 p.R337H mutation sample (melting curve in blue) and a wild typesample (melting curves in green).
Figure 2 Pedigree of patient 1, showing cancer history and the TP53 p.R337H mutation. Arrow indicates the proband; present age or ageat death is indicated below individuals
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