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A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy

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Figure

Table 1: Apparent affinities of HER2bsFab and trastuzumab for human Fcγ receptors.
Figure 1: HER2bsFab simultaneously binds to cell surface HER2 and FcγRIIIA. A) Schematic representation of the assembled HER2bsFab
Figure 2: Anti-proliferative effects mediated by trastuzumab and HER2bsFab. A) SK-BR-3 cells growth was followed for 3, 5 and 7 days in the presence of trastuzumab or HER2bsFab (500 nM)
Figure 3: HER2bsFab mediates potent in vitro ADCC activity similar to trastuzumab against high-HER2-overexpressing cells
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