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Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

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Academic year: 2020

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Figure 1: Canonical and non-canonical TGF-β pathways. In the canonical pathway, the three TGF-β ligand isoforms, TGF-β1, TGF-β2, and TGF-β3, are synthesized as precursors and bind to form the latent TGF-β complex before being secreted[138]
Figure 2: Overview of the effects of TGF-β signalling in PDAC. At the cellular level, TGF-β induces proliferation and survival (fibrotic cells), involved in the production of a dense fibrotic stroma and the resulting low vascularization of PDAC
Table 1: TGF-β pathway inhibitors in development in hepatocellular and pancreatic carcinomas

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