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Hypoxia-targeted 131 I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

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Academic year: 2020

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Figure

Figure 1: Induction of hypoxia-responsive promoter-driven transgene expression under hypoxic conditions in vitro
Figure 2: Enhanced tumoral radioiodide accumulation after systemic HIF-NIS-MSC application in subcutaneous and intrahepatic HuH7 xenograft mouse models
Figure 3: MSC recruitment and hypoxia-induced NIS expression were higher in intrahepatic compared to subcutaneous HCC tumors
Figure 4: Growth inhibition of orthotopic HuH7 tumors after application of a therapeutic dose of radioiodide in HIF-NIS-MSC-treated mice was associated with a prolonged survival
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